4-[2-(4-chloro-3-methoxyphenyl)-octahydro-pyrido[1,2-a]pyrazin-6-yl]-2,3-dimethyl-phenol

Base Information

Chemical Name:4-[2-(4-chloro-3-methoxyphenyl)-octahydro-pyrido[1,2-a]pyrazin-6-yl]-2,3-dimethyl-phenol
CAS No.:873324-86-8
Molecular Formula:C₂₃H₂₉ClN₂O₂
Molecular Weight:400.948
Hs Code.:

Synonyms:4-[2-(4-chloro-3-methoxyphenyl)-octahydro-pyrido[1,2-a]pyrazin-6-yl]-2,3-dimethyl-phenol

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Chemical Property of 4-[2-(4-chloro-3-methoxyphenyl)-octahydro-pyrido[1,2-a]pyrazin-6-yl]-2,3-dimethyl-phenol

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Technology Process of 4-[2-(4-chloro-3-methoxyphenyl)-octahydro-pyrido[1,2-a]pyrazin-6-yl]-2,3-dimethyl-phenol

There total 14 articles about 4-[2-(4-chloro-3-methoxyphenyl)-octahydro-pyrido[1,2-a]pyrazin-6-yl]-2,3-dimethyl-phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 873324-85-7
2-(4-chloro-3-methoxyphenyl)-6-(4-hydroxy-2,3-dimethylphenyl)-octahydro-pyrido[1,2-a]pyrazin-8-one

: 873324-86-8
4-[2-(4-chloro-3-methoxyphenyl)-octahydro-pyrido[1,2-a]pyrazin-6-yl]-2,3-dimethyl-phenol

Guidance literature:: 2-(4-chloro-3-methoxyphenyl)-6-(4-hydroxy-2,3-dimethylphenyl)-octahydro-pyrido[1,2-a]pyrazin-8-one; With toluene-4-sulfonic acid hydrazide; In tetrahydrofuran; methanol; at 20 ℃;

With sodium cyanoborohydride; zinc trifluoromethanesulfonate; In tetrahydrofuran; methanol; at 65 ℃; for 5.08333h;

With sodium hydrogencarbonate; In tetrahydrofuran; methanol; water; at 20 ℃; for 0.25h;

Reference yield:

: 6-(4-allyloxy-2,3-dimethylphenyl)-2-(4-chloro-3-methoxyphenyl)-octahydro-pyrido[1,2-a]pyrazin-8-one

: 873324-86-8
4-[2-(4-chloro-3-methoxyphenyl)-octahydro-pyrido[1,2-a]pyrazin-6-yl]-2,3-dimethyl-phenol

Guidance literature:: Multi-step reaction with 2 steps

1.1: morpholine / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / dichloromethane / 1 h / 20 °C

2.1: toluene-4-sulfonic acid hydrazide / tetrahydrofuran; methanol / 20 °C

2.2: 5.08 h / 65 °C

2.3: 0.25 h / 20 °C

With morpholine; toluene-4-sulfonic acid hydrazide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; dichloromethane;

Reference yield:

: [(6R,9aS)-6-(4-methoxy-2,3-dimethylphenyl)-octahydro-pyrido[1,2-a]pyrazin-2-yl]-(6-trifluoromethyl-pyridin-3-yl)-methanone

: 873324-86-8
4-[2-(4-chloro-3-methoxyphenyl)-octahydro-pyrido[1,2-a]pyrazin-6-yl]-2,3-dimethyl-phenol

Guidance literature:: Multi-step reaction with 6 steps

1.1: hydrogenchloride / diethyl ether; dichloromethane / 0.17 h

1.2: 18.33 h / -70 - 20 °C

1.3: 0.5 h / 0 °C

2.1: potassium hydroxide / acetonitrile / 20.5 h / 60 °C

3.1: hydrogenchloride / methanol; water / 3 h / 60 °C

4.1: ammonium acetate / methanol; 1,1-dichloroethane; water / 0 - 60 °C

4.2: 0.25 h / 0 °C

5.1: morpholine / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / dichloromethane / 1 h / 20 °C

6.1: toluene-4-sulfonic acid hydrazide / tetrahydrofuran; methanol / 20 °C

6.2: 5.08 h / 65 °C

6.3: 0.25 h / 20 °C

With morpholine; hydrogenchloride; potassium hydroxide; ammonium acetate; toluene-4-sulfonic acid hydrazide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; diethyl ether; 1,1-dichloroethane; dichloromethane; water; acetonitrile;