(7aR,11R,13S)-11-vinyl-13-phenyl-7a,8,10,11-tetrahydro-9H,13H-naphtho[1,2-e]pyrido[2,1-b][1,3]oxazine

Base Information

Chemical Name:(7aR,11R,13S)-11-vinyl-13-phenyl-7a,8,10,11-tetrahydro-9H,13H-naphtho[1,2-e]pyrido[2,1-b][1,3]oxazine
CAS No.:1226808-27-0
Molecular Formula:C₂₄H₂₃NO
Molecular Weight:341.453
Hs Code.:

Synonyms:(7aR,11R,13S)-11-vinyl-13-phenyl-7a,8,10,11-tetrahydro-9H,13H-naphtho[1,2-e]pyrido[2,1-b][1,3]oxazine

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Chemical Property of (7aR,11R,13S)-11-vinyl-13-phenyl-7a,8,10,11-tetrahydro-9H,13H-naphtho[1,2-e]pyrido[2,1-b][1,3]oxazine

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Technology Process of (7aR,11R,13S)-11-vinyl-13-phenyl-7a,8,10,11-tetrahydro-9H,13H-naphtho[1,2-e]pyrido[2,1-b][1,3]oxazine

There total 2 articles about (7aR,11R,13S)-11-vinyl-13-phenyl-7a,8,10,11-tetrahydro-9H,13H-naphtho[1,2-e]pyrido[2,1-b][1,3]oxazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 1826-67-1
vinyl magnesium bromide

: 667870-42-0
(7aR,11R,13S)-11-(1H-benzotriazol-1-yl)-7a,8,10,11-tetrahydro-13-phenyl-9H,13H-naphtho[1,2-e]pyrido[2,1-b][1,3]oxazine

: 1226808-27-0
(7aR,11R,13S)-11-vinyl-13-phenyl-7a,8,10,11-tetrahydro-9H,13H-naphtho[1,2-e]pyrido[2,1-b][1,3]oxazine

Guidance literature:: In tetrahydrofuran; at 0 ℃; for 2h; regioselective reaction; Inert atmosphere;
DOI:10.1039/b927007h

Reference yield: 92.0%

: 3536-96-7
vinylmagnesium chloride

: 667870-42-0
(7aR,11R,13S)-11-(1H-benzotriazol-1-yl)-7a,8,10,11-tetrahydro-13-phenyl-9H,13H-naphtho[1,2-e]pyrido[2,1-b][1,3]oxazine

: 1226808-27-0
(7aR,11R,13S)-11-vinyl-13-phenyl-7a,8,10,11-tetrahydro-9H,13H-naphtho[1,2-e]pyrido[2,1-b][1,3]oxazine

Guidance literature:: In tetrahydrofuran; at 0 ℃; for 0.5h; regioselective reaction; Inert atmosphere;
DOI:10.1039/b927007h

Reference yield:

: 1226808-27-0
(7aR,11R,13S)-11-vinyl-13-phenyl-7a,8,10,11-tetrahydro-9H,13H-naphtho[1,2-e]pyrido[2,1-b][1,3]oxazine

: 106-94-5
propyl bromide

: 1281984-15-3
C₂₇H₃₁NO

Guidance literature:: propyl bromide; With magnesium; In diethyl ether;

(7aR,11R,13S)-11-vinyl-13-phenyl-7a,8,10,11-tetrahydro-9H,13H-naphtho[1,2-e]pyrido[2,1-b][1,3]oxazine; In diethyl ether; at 0 ℃; for 0.333333h; Inert atmosphere;
DOI:10.1039/b927007h