2,2-Dimethyl-propionic acid (Z)-(4S,5S,6S)-7-(tert-butyl-diphenyl-silanyloxy)-5-methoxymethoxy-4,6-dimethyl-hept-2-enyl ester

Base Information

Chemical Name:2,2-Dimethyl-propionic acid (Z)-(4S,5S,6S)-7-(tert-butyl-diphenyl-silanyloxy)-5-methoxymethoxy-4,6-dimethyl-hept-2-enyl ester
CAS No.:600714-87-2
Molecular Formula:C₃₂H₄₈O₅Si
Molecular Weight:540.816
Hs Code.:

Synonyms:2,2-Dimethyl-propionic acid (Z)-(4S,5S,6S)-7-(tert-butyl-diphenyl-silanyloxy)-5-methoxymethoxy-4,6-dimethyl-hept-2-enyl ester

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Chemical Property of 2,2-Dimethyl-propionic acid (Z)-(4S,5S,6S)-7-(tert-butyl-diphenyl-silanyloxy)-5-methoxymethoxy-4,6-dimethyl-hept-2-enyl ester

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Technology Process of 2,2-Dimethyl-propionic acid (Z)-(4S,5S,6S)-7-(tert-butyl-diphenyl-silanyloxy)-5-methoxymethoxy-4,6-dimethyl-hept-2-enyl ester

There total 7 articles about 2,2-Dimethyl-propionic acid (Z)-(4S,5S,6S)-7-(tert-butyl-diphenyl-silanyloxy)-5-methoxymethoxy-4,6-dimethyl-hept-2-enyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 92817-88-4
(2S)-3-{[tert-butyl(diphenyl)silyl]oxy}-2-methylpropanal

: 600714-87-2
2,2-Dimethyl-propionic acid (Z)-(4S,5S,6S)-7-(tert-butyl-diphenyl-silanyloxy)-5-methoxymethoxy-4,6-dimethyl-hept-2-enyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 91 percent / diethyl ether / -78 °C

2: 89 percent / (i-Pr)2NEt / CH₂Cl₂ / -78 °C

3: 85 percent / Grubbs' catalyst / CH₂Cl₂ / Heating

4: Dibal-H / CH₂Cl₂ / -78 °C

5: NaBH₄ / methanol / 0 °C

6: pyridine / 25 °C

7: (i-Pr)2NEt / CH₂Cl₂ / 25 °C

With pyridine; sodium tetrahydroborate; diisobutylaluminium hydride; N-ethyl-N,N-diisopropylamine; Grubbs catalyst first generation; In methanol; diethyl ether; dichloromethane;
DOI:10.1021/ol034958l

Reference yield:

: 106357-24-8
(3S,4S,5S)-6-(tert-butyldiphenylsiloxy)-4-hydroxy-3,5-dimethylhexan-1-ene

: 600714-87-2
2,2-Dimethyl-propionic acid (Z)-(4S,5S,6S)-7-(tert-butyl-diphenyl-silanyloxy)-5-methoxymethoxy-4,6-dimethyl-hept-2-enyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 89 percent / (i-Pr)2NEt / CH₂Cl₂ / -78 °C

2: 85 percent / Grubbs' catalyst / CH₂Cl₂ / Heating

3: Dibal-H / CH₂Cl₂ / -78 °C

4: NaBH₄ / methanol / 0 °C

5: pyridine / 25 °C

6: (i-Pr)2NEt / CH₂Cl₂ / 25 °C

With pyridine; sodium tetrahydroborate; diisobutylaluminium hydride; N-ethyl-N,N-diisopropylamine; Grubbs catalyst first generation; In methanol; dichloromethane;
DOI:10.1021/ol034958l

Reference yield:

: 468738-71-8
(1S,2S)-1-{(1S)-2-[(tert-butyldiphenylsilyl)oxy]-1-methylethyl}-2-methylbut-3-enyl prop-2-enoate

: 600714-87-2
2,2-Dimethyl-propionic acid (Z)-(4S,5S,6S)-7-(tert-butyl-diphenyl-silanyloxy)-5-methoxymethoxy-4,6-dimethyl-hept-2-enyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 85 percent / Grubbs' catalyst / CH₂Cl₂ / Heating

2: Dibal-H / CH₂Cl₂ / -78 °C

3: NaBH₄ / methanol / 0 °C

4: pyridine / 25 °C

5: (i-Pr)2NEt / CH₂Cl₂ / 25 °C

With pyridine; sodium tetrahydroborate; diisobutylaluminium hydride; N-ethyl-N,N-diisopropylamine; Grubbs catalyst first generation; In methanol; dichloromethane;
DOI:10.1021/ol034958l