1-(3,5-dibenzyloxy-4-methoxybenzyl)-6-methoxy-3,4-dihydroisoquinoline

Base Information

Chemical Name:1-(3,5-dibenzyloxy-4-methoxybenzyl)-6-methoxy-3,4-dihydroisoquinoline
CAS No.:54186-44-6
Molecular Formula:C₃₂H₃₁NO₄
Molecular Weight:493.602
Hs Code.:

Synonyms:1-(3,5-dibenzyloxy-4-methoxybenzyl)-6-methoxy-3,4-dihydroisoquinoline

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Chemical Property of 1-(3,5-dibenzyloxy-4-methoxybenzyl)-6-methoxy-3,4-dihydroisoquinoline

Chemical Property:

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Technology Process of 1-(3,5-dibenzyloxy-4-methoxybenzyl)-6-methoxy-3,4-dihydroisoquinoline

There total 3 articles about 1-(3,5-dibenzyloxy-4-methoxybenzyl)-6-methoxy-3,4-dihydroisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1402404-92-5
1,3-bis(benzyloxy)-5-(bromomethyl)-2-methoxybenzene

: 6-methoxy-1,2,3,4-tetrahydroisoquinoline-1-carbonitrile

: 54186-44-6
1-(3,5-dibenzyloxy-4-methoxybenzyl)-6-methoxy-3,4-dihydroisoquinoline

Guidance literature:: 6-methoxy-1,2,3,4-tetrahydroisoquinoline-1-carbonitrile; With potassium hexamethylsilazane; In tetrahydrofuran; at -78 ℃; for 0.0833333h; Inert atmosphere;

1,3-bis(benzyloxy)-5-(bromomethyl)-2-methoxybenzene; In tetrahydrofuran; at -78 - 20 ℃; for 3h; Inert atmosphere;
DOI:10.1021/ol5023849

Reference yield:

: 14446-29-8
6-Methoxy-3,4-dihydroisoquinoline

: 54186-44-6
1-(3,5-dibenzyloxy-4-methoxybenzyl)-6-methoxy-3,4-dihydroisoquinoline

Guidance literature:: Multi-step reaction with 2 steps

1.1: water / 20 °C

2.1: potassium hexamethylsilazane / tetrahydrofuran / 0.08 h / -78 °C / Inert atmosphere

2.2: 3 h / -78 - 20 °C / Inert atmosphere

With potassium hexamethylsilazane; In tetrahydrofuran; water;
DOI:10.1021/ol5023849

Reference yield:

: 27229-56-7
[3,5-bis(benzyloxy)-4-methoxyphenyl]methanol

: 54186-44-6
1-(3,5-dibenzyloxy-4-methoxybenzyl)-6-methoxy-3,4-dihydroisoquinoline

Guidance literature:: Multi-step reaction with 2 steps

1.1: triphenylphosphine; N-Bromosuccinimide / tetrahydrofuran / 2.5 h / 0 - 20 °C / Inert atmosphere

2.1: potassium hexamethylsilazane / tetrahydrofuran / 0.08 h / -78 °C / Inert atmosphere

2.2: 3 h / -78 - 20 °C / Inert atmosphere

With N-Bromosuccinimide; potassium hexamethylsilazane; triphenylphosphine; In tetrahydrofuran;
DOI:10.1021/ol5023849