methyl 2-hydroxy-3-iodo-6-methyl-4-[(triisopropylsiloxy)methyl]benzoate

Base Information

Chemical Name:methyl 2-hydroxy-3-iodo-6-methyl-4-[(triisopropylsiloxy)methyl]benzoate
CAS No.:863423-74-9
Molecular Formula:C₁₉H₃₁IO₄Si
Molecular Weight:478.443
Hs Code.:

Synonyms:methyl 2-hydroxy-3-iodo-6-methyl-4-[(triisopropylsiloxy)methyl]benzoate

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Chemical Property of methyl 2-hydroxy-3-iodo-6-methyl-4-[(triisopropylsiloxy)methyl]benzoate

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Technology Process of methyl 2-hydroxy-3-iodo-6-methyl-4-[(triisopropylsiloxy)methyl]benzoate

There total 1 articles about methyl 2-hydroxy-3-iodo-6-methyl-4-[(triisopropylsiloxy)methyl]benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1007853-47-5
methyl 2-hydroxy-6-methyl-4-[(triisopropylsiloxy)methyl]benzoate

: 863423-74-9
methyl 2-hydroxy-3-iodo-6-methyl-4-[(triisopropylsiloxy)methyl]benzoate

Guidance literature:: With sodium hydrogencarbonate; In methanol; dichloromethane; at 20 ℃; for 4h;
DOI:10.1002/chem.200700863

Reference yield: 99.0%

: 863423-73-8
7-chloro-5,8-dimethoxy-4-methoxymethoxy-2-naphthoic acid

: 863423-74-9
methyl 2-hydroxy-3-iodo-6-methyl-4-[(triisopropylsiloxy)methyl]benzoate

: 863423-90-9
2-iodo-6-methoxycarbonyl-5-methyl-3-[(triisopropylsiloxy)methyl]phenyl 7-chloro-5,8-dimethoxy-4-methoxymethoxy-2-naphthoate

Guidance literature:: With dmap; 2,4,6-trichlorobenzoyl chloride; triethylamine; In toluene; at 20 ℃; for 0.333333h;
DOI:10.1002/anie.200501210

Reference yield:

: 863423-74-9
methyl 2-hydroxy-3-iodo-6-methyl-4-[(triisopropylsiloxy)methyl]benzoate

: 2-benzyloxy-3-[1-benzyloxy-3-(bis-benzyloxy-methyl)-6-chloro-5,8-dimethoxy-naphthalen-2-yl]-4-formyl-6-methyl-benzoic acid methyl ester

Guidance literature:: Multi-step reaction with 11 steps

1.1: 99 percent / 2,4,6-trichlorobenzoyl chloride; Et₃N; 4-(dimethylamino)pyridine / toluene / 0.33 h / 20 °C

2.1: 96 percent / CF₃COOH / CH₂Cl₂ / 4 h / 25 °C

3.1: 60 percent / PPh₃; tBuCO₂Na / Pd(OAc)2 / N,N-dimethyl-acetamide / 60 h / 110 °C

4.1: CH₂Cl₂ / 43 h / 0 °C

5.1: 97 percent / Cs₂CO₃ / dimethylformamide / 1.17 h / 0 - 20 °C

6.1: 100 percent / I₂; PPh₃; imidazole / CH₂Cl₂ / 0.33 h / 0 °C

7.1: 2.6-di-tert-butylpyridine / CH₂Cl₂ / 1 h / 20 °C

8.1: L-Selectride / 0.33 h / 0 °C

8.2: 96 percent / silica gel / 17 h / 20 °C

9.1: trimethylsilyl trifluoromethanesulfonate / toluene / 6 h / -15 °C

10.1: nBu₄NF / tetrahydrofuran / 1 h / 0 °C

11.1: MnO₂ / CH₂Cl₂ / 16 h / 20 °C

With 1H-imidazole; dmap; manganese(IV) oxide; 2,6-di-tert-butyl-pyridine; trimethylsilyl trifluoromethanesulfonate; 2,4,6-trichlorobenzoyl chloride; tetrabutyl ammonium fluoride; iodine; L-Selectride; sodium pivalate; caesium carbonate; triethylamine; triphenylphosphine; trifluoroacetic acid; palladium diacetate; In tetrahydrofuran; dichloromethane; N,N-dimethyl acetamide; N,N-dimethyl-formamide; toluene; 1.1: Yamaguchi esterification;
DOI:10.1002/anie.200501210