2-iodo-6-methoxycarbonyl-5-methyl-3-[(triisopropylsiloxy)methyl]phenyl 7-chloro-5,8-dimethoxy-4-methoxymethoxy-2-naphthoate

Base Information

Chemical Name:2-iodo-6-methoxycarbonyl-5-methyl-3-[(triisopropylsiloxy)methyl]phenyl 7-chloro-5,8-dimethoxy-4-methoxymethoxy-2-naphthoate
CAS No.:863423-90-9
Molecular Formula:C₃₄H₄₄ClIO₉Si
Molecular Weight:787.161
Hs Code.:

Synonyms:2-iodo-6-methoxycarbonyl-5-methyl-3-[(triisopropylsiloxy)methyl]phenyl 7-chloro-5,8-dimethoxy-4-methoxymethoxy-2-naphthoate

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Chemical Property of 2-iodo-6-methoxycarbonyl-5-methyl-3-[(triisopropylsiloxy)methyl]phenyl 7-chloro-5,8-dimethoxy-4-methoxymethoxy-2-naphthoate

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Technology Process of 2-iodo-6-methoxycarbonyl-5-methyl-3-[(triisopropylsiloxy)methyl]phenyl 7-chloro-5,8-dimethoxy-4-methoxymethoxy-2-naphthoate

There total 1 articles about 2-iodo-6-methoxycarbonyl-5-methyl-3-[(triisopropylsiloxy)methyl]phenyl 7-chloro-5,8-dimethoxy-4-methoxymethoxy-2-naphthoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 863423-73-8
7-chloro-5,8-dimethoxy-4-methoxymethoxy-2-naphthoic acid

: 863423-74-9
methyl 2-hydroxy-3-iodo-6-methyl-4-[(triisopropylsiloxy)methyl]benzoate

: 863423-90-9
2-iodo-6-methoxycarbonyl-5-methyl-3-[(triisopropylsiloxy)methyl]phenyl 7-chloro-5,8-dimethoxy-4-methoxymethoxy-2-naphthoate

Guidance literature:: With dmap; 2,4,6-trichlorobenzoyl chloride; triethylamine; In toluene; at 20 ℃; for 0.333333h;
DOI:10.1002/anie.200501210

Reference yield: 99.0%

: 863423-90-9
2-iodo-6-methoxycarbonyl-5-methyl-3-[(triisopropylsiloxy)methyl]phenyl 7-chloro-5,8-dimethoxy-4-methoxymethoxy-2-naphthoate

: 863423-89-6
2-iodo-6-methoxycarbonyl-5-methyl-3-[(triisopropylsiloxy)methyl]phenyl 7-chloro-4-hydroxy-5,8-dimethoxy-2-naphthoate

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 3.5h;
DOI:10.1002/chem.200700863

Reference yield:

: 863423-90-9
2-iodo-6-methoxycarbonyl-5-methyl-3-[(triisopropylsiloxy)methyl]phenyl 7-chloro-5,8-dimethoxy-4-methoxymethoxy-2-naphthoate

: 3-(6-chloro-1-hydroxy-3-hydroxymethyl-5,8-dimethoxy-naphthalen-2-yl)-2-hydroxy-6-methyl-4-triisopropylsilanyloxymethyl-benzoic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 96 percent / CF₃COOH / CH₂Cl₂ / 4 h / 25 °C

2: 60 percent / PPh₃; tBuCO₂Na / Pd(OAc)2 / N,N-dimethyl-acetamide / 60 h / 110 °C

3: NaBH₄

With sodium tetrahydroborate; sodium pivalate; triphenylphosphine; trifluoroacetic acid; palladium diacetate; In dichloromethane; N,N-dimethyl acetamide;
DOI:10.1002/anie.200501210