2-[1-(3-Chloro-phenyl)-meth-(Z)-ylidene]-3-oxo-butyric acid tert-butyl ester

Base Information

• Chemical Name: 2-[1-(3-Chloro-phenyl)-meth-(Z)-ylidene]-3-oxo-butyric acid tert-butyl ester
• CAS No.: 98050-57-8
• Molecular Formula: C₁₅H₁₇ClO₃
• Molecular Weight: 280.751

Synonyms:2-[1-(3-Chloro-phenyl)-meth-(Z)-ylidene]-3-oxo-butyric acid tert-butyl ester

Chemical Property of 2-[1-(3-Chloro-phenyl)-meth-(Z)-ylidene]-3-oxo-butyric acid tert-butyl ester

Chemical Property:

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Technology Process of 2-[1-(3-Chloro-phenyl)-meth-(Z)-ylidene]-3-oxo-butyric acid tert-butyl ester

There total 1 articles about 2-[1-(3-Chloro-phenyl)-meth-(Z)-ylidene]-3-oxo-butyric acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butyl acetoacetate (1694-31-1) + m-Chlorobenzaldehyde (587-04-2) → C15H17ClO3 (98050-57-8)

Guidance literature:

With piperidine; acetic acid; In toluene; Reflux;

DOI:10.1016/j.bmcl.2008.10.099

Reference yield: 99.0%

acetamidine hydrochloride (124-42-5) + 2-[1-(3-Chloro-phenyl)-meth-(Z)-ylidene]-3-oxo-butyric acid tert-butyl ester (98050-57-8) → 5-(tert-butoxycarbonyl)-4-(m-chlorophenyl)-6-hydroxy-2,6-dimethyl-1,4,5,6-tetrahydropyrimidine (98050-62-5)

Guidance literature:

With potassium tert-butylate; In tert-butyl alcohol; for 1h; Ambient temperature;

DOI:10.1021/jo00222a009

Reference yield:

3-aminopyrazole (1820-80-0,916420-28-5) + C15H17ClO3 (98050-57-8) → C18H20ClN3O2

Guidance literature:

With sodium acetate; In N,N-dimethyl-formamide; at 70 ℃; for 17h;

DOI:10.1016/j.bmcl.2008.10.099

upstream raw materials:

tert-butyl acetoacetate

m-Chlorobenzaldehyde

Downstream raw materials:

5-(tert-butoxycarbonyl)-4-(m-chlorophenyl)-6-hydroxy-2,6-dimethyl-1,4,5,6-tetrahydropyrimidine

5-(tert-butoxycarbonyl)-4-(m-chlorophenyl)-2,6-dimethyl-1,4(3,4)-dihydropyrimidine

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