4-(4-Benzyl-5-oxo-2-phenyl-4,5-dihydro-oxazol-4-yl)-2-methyl-4-oxo-butyric acid methyl ester

Base Information

• Chemical Name: 4-(4-Benzyl-5-oxo-2-phenyl-4,5-dihydro-oxazol-4-yl)-2-methyl-4-oxo-butyric acid methyl ester
• CAS No.: 83084-78-0
• Molecular Formula: C₂₂H₂₁NO₅
• Molecular Weight: 379.412

Synonyms:4-(4-Benzyl-5-oxo-2-phenyl-4,5-dihydro-oxazol-4-yl)-2-methyl-4-oxo-butyric acid methyl ester

Chemical Property of 4-(4-Benzyl-5-oxo-2-phenyl-4,5-dihydro-oxazol-4-yl)-2-methyl-4-oxo-butyric acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(4-Benzyl-5-oxo-2-phenyl-4,5-dihydro-oxazol-4-yl)-2-methyl-4-oxo-butyric acid methyl ester

There total 5 articles about 4-(4-Benzyl-5-oxo-2-phenyl-4,5-dihydro-oxazol-4-yl)-2-methyl-4-oxo-butyric acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-methylbutanedioic acid (498-21-5,636-60-2) → (R)-4-(4-Benzyl-5-oxo-2-phenyl-4,5-dihydro-oxazol-4-yl)-2-methyl-4-oxo-butyric acid methyl ester (83084-78-0)

Guidance literature:

Multi-step reaction with 3 steps

2: 49.4 percent / 10percent aq. NaOH / diethyl ether / 0 °C

With sodium hydroxide; In diethyl ether;

DOI:10.1021/jm00353a005

Reference yield:

2-(R)-methylsuccinic acid (3641-51-8) → (R)-4-(4-Benzyl-5-oxo-2-phenyl-4,5-dihydro-oxazol-4-yl)-2-methyl-4-oxo-butyric acid methyl ester (83084-78-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 49.4 percent / 10percent aq. NaOH / diethyl ether / 0 °C

With sodium hydroxide; In diethyl ether;

DOI:10.1021/jm00353a005

Reference yield:

methyl 2-methylsuccinate (21307-96-0,22644-27-5,63163-08-6,1604-11-1) → 4-(4-Benzyl-5-oxo-2-phenyl-4,5-dihydro-oxazol-4-yl)-2-methyl-4-oxo-butyric acid methyl ester (83084-78-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) KOH, 2.) oxalyl chloride / 1.) methanol, 5 deg C, 50 h, 2.) benzene, 35 deg C, 3 h

2: 42.5 g / Et₃N / tetrahydrofuran / 16 h / Ambient temperature

With potassium hydroxide; oxalyl dichloride; triethylamine; In tetrahydrofuran;

DOI:10.1021/jm00353a005

upstream raw materials:

4-benzyl-2-phenyl-2-oxazolin-5-one

3-Carbomethoxybutyryl chloride

methyl 2-methylsuccinate

(R)-methylsuccinic acid dimethyl ester

Downstream raw materials:

5-benzamido-2(R)-methyl-4-oxo-6-phenylhexanoyl-L-proline

5-benzamido-2-methyl-4-oxo-6-phenylhexanoyl-L-proline

(S)-1-((2R,5S)-5-Benzoylamino-2-methyl-4-oxo-6-phenyl-hexanoyl)-pyrrolidine-2-carboxylic acid

(S)-1-((2R,5R)-5-Benzoylamino-2-methyl-4-oxo-6-phenyl-hexanoyl)-pyrrolidine-2-carboxylic acid

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 83084-78-0 4-(4-Benzyl-5-oxo-2-phenyl-4,5-dihydro-oxazol-4-yl)-2-methyl-4-oxo-butyric acid methyl ester

Send

Send

Metric Ton KG G Pound L ML

Send

Send