Benzoic acid (2R,3R,4S,5R)-4-(tert-butyl-dimethyl-silanyloxy)-3-fluoro-5-methoxy-tetrahydro-furan-2-ylmethyl ester

Base Information

Chemical Name:Benzoic acid (2R,3R,4S,5R)-4-(tert-butyl-dimethyl-silanyloxy)-3-fluoro-5-methoxy-tetrahydro-furan-2-ylmethyl ester
CAS No.:551929-61-4
Molecular Formula:C₁₉H₂₉FO₅Si
Molecular Weight:384.52
Hs Code.:

Synonyms:Benzoic acid (2R,3R,4S,5R)-4-(tert-butyl-dimethyl-silanyloxy)-3-fluoro-5-methoxy-tetrahydro-furan-2-ylmethyl ester

Suppliers and Price of Benzoic acid (2R,3R,4S,5R)-4-(tert-butyl-dimethyl-silanyloxy)-3-fluoro-5-methoxy-tetrahydro-furan-2-ylmethyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Benzoic acid (2R,3R,4S,5R)-4-(tert-butyl-dimethyl-silanyloxy)-3-fluoro-5-methoxy-tetrahydro-furan-2-ylmethyl ester

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of Benzoic acid (2R,3R,4S,5R)-4-(tert-butyl-dimethyl-silanyloxy)-3-fluoro-5-methoxy-tetrahydro-furan-2-ylmethyl ester

There total 8 articles about Benzoic acid (2R,3R,4S,5R)-4-(tert-butyl-dimethyl-silanyloxy)-3-fluoro-5-methoxy-tetrahydro-furan-2-ylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 18162-48-6
tert-butyldimethylsilyl chloride

: 237410-10-5
((2R,3S,4S,5R)-3-fluoro-4-hydroxy-5-methoxytetrahydrofuran-2-yl)methyl benzoate

: 551929-61-4
Benzoic acid (2R,3R,4S,5R)-4-(tert-butyl-dimethyl-silanyloxy)-3-fluoro-5-methoxy-tetrahydro-furan-2-ylmethyl ester

Guidance literature:: With 1H-imidazole; at 20 ℃; for 6h;
DOI:10.1016/S0960-894X(03)00027-1

Reference yield:

: 152711-00-7
Methyl 3-deoxy-3-fluoro-β-D-arabinofuranoside

: 551929-61-4
Benzoic acid (2R,3R,4S,5R)-4-(tert-butyl-dimethyl-silanyloxy)-3-fluoro-5-methoxy-tetrahydro-furan-2-ylmethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: pyridine

2: 52 percent / 18-crown-6 / dimethylsulfoxide / Heating

With pyridine; 18-crown-6 ether; In dimethyl sulfoxide;
DOI:10.1081/NCN-120022701

Reference yield:

: 43168-73-6
methyl 2,3-anhydro-β-D-lyxofuranoside

: 551929-61-4
Benzoic acid (2R,3R,4S,5R)-4-(tert-butyl-dimethyl-silanyloxy)-3-fluoro-5-methoxy-tetrahydro-furan-2-ylmethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 82 percent / KHF₂; NaF / ethane-1,2-diol / Heating

2: pyridine

3: 52 percent / 18-crown-6 / dimethylsulfoxide / Heating

With pyridine; potassium hydrogen bifluoride; 18-crown-6 ether; sodium fluoride; In ethylene glycol; dimethyl sulfoxide;
DOI:10.1081/NCN-120022701