3-{4-[4-(4-chlorophenyl)piperazin-1-ylmethyl]piperidine-1-sulfonyl}quinoline hydrochloride

Base Information

Chemical Name:3-{4-[4-(4-chlorophenyl)piperazin-1-ylmethyl]piperidine-1-sulfonyl}quinoline hydrochloride
CAS No.:1360625-61-1
Molecular Formula:C₂₅H₂₉ClN₄O₂S*ClH
Molecular Weight:521.511
Hs Code.:

Synonyms:3-{4-[4-(4-chlorophenyl)piperazin-1-ylmethyl]piperidine-1-sulfonyl}quinoline hydrochloride

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Chemical Property of 3-{4-[4-(4-chlorophenyl)piperazin-1-ylmethyl]piperidine-1-sulfonyl}quinoline hydrochloride

Chemical Property:

Purity/Quality:

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Technology Process of 3-{4-[4-(4-chlorophenyl)piperazin-1-ylmethyl]piperidine-1-sulfonyl}quinoline hydrochloride

There total 4 articles about 3-{4-[4-(4-chlorophenyl)piperazin-1-ylmethyl]piperidine-1-sulfonyl}quinoline hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1360684-74-7
3-{4-[4-(4-chlorophenyl)piperazin-1-ylmethyl]piperidine-1-sulfonyl}quinoline

: 1360625-61-1
3-{4-[4-(4-chlorophenyl)piperazin-1-ylmethyl]piperidine-1-sulfonyl}quinoline hydrochloride

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; ethanol;
DOI:10.1016/j.bmc.2011.12.039

Reference yield:

: 166815-96-9
N-tert-butoxycarbonyl-4-(4-toluenesulphonyloxymethyl)piperidine

: 1360625-61-1
3-{4-[4-(4-chlorophenyl)piperazin-1-ylmethyl]piperidine-1-sulfonyl}quinoline hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine / tetrahydrofuran; toluene / 20 h / Reflux

2.1: trifluoroacetic acid / dichloromethane

2.2: 0 °C / Cooling

3.1: hydrogenchloride / 1,4-dioxane; ethanol

With hydrogenchloride; triethylamine; trifluoroacetic acid; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; toluene;
DOI:10.1016/j.bmc.2011.12.039

Reference yield:

: 123855-51-6
tert-butyl 4-(hydroxymethyl)piperidin-1-carboxylate

: 1360625-61-1
3-{4-[4-(4-chlorophenyl)piperazin-1-ylmethyl]piperidine-1-sulfonyl}quinoline hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1.1: pyridine / 13 h / 20 °C / Inert atmosphere; Cooling with ice

2.1: triethylamine / tetrahydrofuran; toluene / 20 h / Reflux

3.1: trifluoroacetic acid / dichloromethane

3.2: 0 °C / Cooling

4.1: hydrogenchloride / 1,4-dioxane; ethanol

With pyridine; hydrogenchloride; triethylamine; trifluoroacetic acid; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; toluene;
DOI:10.1016/j.bmc.2011.12.039