(4-(3-(4-chlorophenyl)imidazo[1,2-b]pyridazin-6-yl)-2-methylphenyl)(4-methylpiperazin-1-yl)methanone

Base Information

Chemical Name:(4-(3-(4-chlorophenyl)imidazo[1,2-b]pyridazin-6-yl)-2-methylphenyl)(4-methylpiperazin-1-yl)methanone
CAS No.:1464151-20-9
Molecular Formula:C₂₅H₂₄ClN₅O
Molecular Weight:445.951
Hs Code.:

Synonyms:(4-(3-(4-chlorophenyl)imidazo[1,2-b]pyridazin-6-yl)-2-methylphenyl)(4-methylpiperazin-1-yl)methanone

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Chemical Property of (4-(3-(4-chlorophenyl)imidazo[1,2-b]pyridazin-6-yl)-2-methylphenyl)(4-methylpiperazin-1-yl)methanone

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Technology Process of (4-(3-(4-chlorophenyl)imidazo[1,2-b]pyridazin-6-yl)-2-methylphenyl)(4-methylpiperazin-1-yl)methanone

There total 4 articles about (4-(3-(4-chlorophenyl)imidazo[1,2-b]pyridazin-6-yl)-2-methylphenyl)(4-methylpiperazin-1-yl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 109-01-3
1-methyl-piperazine

: 1464155-30-3
4-(3-(4-chlorophenyl)imidazo[1,2-b]pyridazin-6-yl)-2-methylbenzoic acid

: 1464151-20-9
(4-(3-(4-chlorophenyl)imidazo[1,2-b]pyridazin-6-yl)-2-methylphenyl)(4-methylpiperazin-1-yl)methanone

Guidance literature:: 4-(3-(4-chlorophenyl)imidazo[1,2-b]pyridazin-6-yl)-2-methylbenzoic acid; With 4-methyl-morpholine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 1h; Inert atmosphere;

1-methyl-piperazine; In N,N-dimethyl-formamide; at 20 ℃; for 18h;

Reference yield:

: 1679-18-1
4-Chlorophenylboronic acid

: 1464151-20-9
(4-(3-(4-chlorophenyl)imidazo[1,2-b]pyridazin-6-yl)-2-methylphenyl)(4-methylpiperazin-1-yl)methanone

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 18 h / Inert atmosphere; Reflux

2.1: potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; N,N-dimethyl-formamide / 18 h / 80 °C / Inert atmosphere

3.1: 4-methyl-morpholine; HATU / N,N-dimethyl-formamide / 1 h / 20 °C / Inert atmosphere

3.2: 18 h / 20 °C

With 4-methyl-morpholine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate; potassium carbonate; HATU; In 1,4-dioxane; water; N,N-dimethyl-formamide;

Reference yield:

: 1025065-97-7
6-chloro-3-(4-chlorophenyl)imidazo[1,2-b]pyridazine

: 1464151-20-9
(4-(3-(4-chlorophenyl)imidazo[1,2-b]pyridazin-6-yl)-2-methylphenyl)(4-methylpiperazin-1-yl)methanone

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; N,N-dimethyl-formamide / 18 h / 80 °C / Inert atmosphere

2.1: 4-methyl-morpholine; HATU / N,N-dimethyl-formamide / 1 h / 20 °C / Inert atmosphere

2.2: 18 h / 20 °C

With 4-methyl-morpholine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate; HATU; In water; N,N-dimethyl-formamide;