methyl 3-{2-methoxy-5-[1-oxo-2-(3-bromophenyl)ethyl]phenyl}phenylacetate

Base Information

Chemical Name:methyl 3-{2-methoxy-5-[1-oxo-2-(3-bromophenyl)ethyl]phenyl}phenylacetate
CAS No.:204571-87-9
Molecular Formula:C₂₄H₂₁BrO₄
Molecular Weight:453.332
Hs Code.:

Synonyms:methyl 3-{2-methoxy-5-[1-oxo-2-(3-bromophenyl)ethyl]phenyl}phenylacetate

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Chemical Property of methyl 3-{2-methoxy-5-[1-oxo-2-(3-bromophenyl)ethyl]phenyl}phenylacetate

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Technology Process of methyl 3-{2-methoxy-5-[1-oxo-2-(3-bromophenyl)ethyl]phenyl}phenylacetate

There total 1 articles about methyl 3-{2-methoxy-5-[1-oxo-2-(3-bromophenyl)ethyl]phenyl}phenylacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 98288-51-8
2-(3-bromophenyl)acetyl chloride

: 171905-89-8
methyl 3-(2-methoxyphenyl)phenylacetate

: 204571-87-9
methyl 3-{2-methoxy-5-[1-oxo-2-(3-bromophenyl)ethyl]phenyl}phenylacetate

Guidance literature:: With aluminium trichloride; In 1,2-dichloro-ethane; at 50 ℃; for 15h;
DOI:10.1021/jm9704917

Reference yield: 77.0%

: 5720-06-9
2-Methoxyphenylboronic acid

: 204571-87-9
methyl 3-{2-methoxy-5-[1-oxo-2-(3-bromophenyl)ethyl]phenyl}phenylacetate

: 204571-88-0
methyl 3-(2-methoxy-5-{1-oxo-2-[3-(2-methoxyphenyl)phenyl]ethyl}phenyl)phenylacetate

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In toluene; for 14h; Heating;
DOI:10.1021/jm9704917

Reference yield:

: 204571-87-9
methyl 3-{2-methoxy-5-[1-oxo-2-(3-bromophenyl)ethyl]phenyl}phenylacetate

: {2'-Hydroxy-5'-[2-(2'-hydroxy-biphenyl-3-yl)-ethyl]-biphenyl-3-yl}-acetic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 77 percent / tetrakis(triphenylphosphine)palladium⁽⁰⁾, 2N aq. Na₂CO₃ / toluene / 14 h / Heating

2: 2N aq. KOH / dimethylsulfoxide / 1 h / 60 °C

3: 1.) hydrazine hydrate, 2.) t-BuOK / 1.) 60 deg C, 1 h, 2.) 100 deg C, 18 h

4: BBr₃ / CH₂Cl₂ / 4 h / -78 - 0 °C

With potassium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium tert-butylate; boron tribromide; sodium carbonate; hydrazine hydrate; In dichloromethane; dimethyl sulfoxide; toluene;
DOI:10.1021/jm9704917