methyl 3-(2-methoxy-5-{1-oxo-2-[3-(2-methoxyphenyl)phenyl]ethyl}phenyl)phenylacetate

Base Information

• Chemical Name: methyl 3-(2-methoxy-5-{1-oxo-2-[3-(2-methoxyphenyl)phenyl]ethyl}phenyl)phenylacetate
• CAS No.: 204571-88-0
• Molecular Formula: C₃₁H₂₈O₅
• Molecular Weight: 480.56
• Mol file: 204571-88-0.mol

Synonyms:methyl 3-(2-methoxy-5-{1-oxo-2-[3-(2-methoxyphenyl)phenyl]ethyl}phenyl)phenylacetate

Chemical Property of methyl 3-(2-methoxy-5-{1-oxo-2-[3-(2-methoxyphenyl)phenyl]ethyl}phenyl)phenylacetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 3-(2-methoxy-5-{1-oxo-2-[3-(2-methoxyphenyl)phenyl]ethyl}phenyl)phenylacetate

There total 3 articles about methyl 3-(2-methoxy-5-{1-oxo-2-[3-(2-methoxyphenyl)phenyl]ethyl}phenyl)phenylacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

2-Methoxyphenylboronic acid (5720-06-9) + methyl 3-{2-methoxy-5-[1-oxo-2-(3-bromophenyl)ethyl]phenyl}phenylacetate (204571-87-9) → methyl 3-(2-methoxy-5-{1-oxo-2-[3-(2-methoxyphenyl)phenyl]ethyl}phenyl)phenylacetate (204571-88-0)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In toluene; for 14h; Heating;

DOI:10.1021/jm9704917

Reference yield:

2-(3-bromophenyl)acetyl chloride (98288-51-8) → methyl 3-(2-methoxy-5-{1-oxo-2-[3-(2-methoxyphenyl)phenyl]ethyl}phenyl)phenylacetate (204571-88-0)

Guidance literature:

Multi-step reaction with 2 steps

1: AlCl₃ / 1,2-dichloro-ethane / 15 h / 50 °C

2: 77 percent / tetrakis(triphenylphosphine)palladium⁽⁰⁾, 2N aq. Na₂CO₃ / toluene / 14 h / Heating

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; aluminium trichloride; sodium carbonate; In 1,2-dichloro-ethane; toluene;

DOI:10.1021/jm9704917

Reference yield:

methyl 3-(2-methoxyphenyl)phenylacetate (171905-89-8) → methyl 3-(2-methoxy-5-{1-oxo-2-[3-(2-methoxyphenyl)phenyl]ethyl}phenyl)phenylacetate (204571-88-0)

Guidance literature:

Multi-step reaction with 2 steps

1: AlCl₃ / 1,2-dichloro-ethane / 15 h / 50 °C

2: 77 percent / tetrakis(triphenylphosphine)palladium⁽⁰⁾, 2N aq. Na₂CO₃ / toluene / 14 h / Heating

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; aluminium trichloride; sodium carbonate; In 1,2-dichloro-ethane; toluene;

DOI:10.1021/jm9704917

upstream raw materials:

2-Methoxyphenylboronic acid

methyl 3-{2-methoxy-5-[1-oxo-2-(3-bromophenyl)ethyl]phenyl}phenylacetate

2-(3-bromophenyl)acetyl chloride

methyl 3-(2-methoxyphenyl)phenylacetate

Downstream raw materials:

(2'-((2R,3S,4S,5R,6R)-3,4,5-Triacetoxy-6-acetoxymethyl-tetrahydro-pyran-2-yloxy)-5'-{2-[2'-((2R,3S,4S,5R,6R)-3,4,5-triacetoxy-6-acetoxymethyl-tetrahydro-pyran-2-yloxy)-biphenyl-3-yl]-ethyl}-biphenyl-3-yl)-acetic acid methyl ester

methyl 3-(2-hydroxy-5-{2-[3-(2-hydroxyphenyl)phenyl]ethyl}phenyl)phenylacetate