(3R,3'R)-4,4'-((4R,6R)-2,2-dimethyl-1,3-dioxane-4,6-diyl)bis(3-((tert-butyldiphenylsilyl)oxy)butan-1-ol)

Base Information

Chemical Name:(3R,3'R)-4,4'-((4R,6R)-2,2-dimethyl-1,3-dioxane-4,6-diyl)bis(3-((tert-butyldiphenylsilyl)oxy)butan-1-ol)
CAS No.:1290537-63-1
Molecular Formula:C₄₆H₆₄O₆Si₂
Molecular Weight:769.182
Hs Code.:

Synonyms:(3R,3'R)-4,4'-((4R,6R)-2,2-dimethyl-1,3-dioxane-4,6-diyl)bis(3-((tert-butyldiphenylsilyl)oxy)butan-1-ol)

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Chemical Property of (3R,3'R)-4,4'-((4R,6R)-2,2-dimethyl-1,3-dioxane-4,6-diyl)bis(3-((tert-butyldiphenylsilyl)oxy)butan-1-ol)

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Technology Process of (3R,3'R)-4,4'-((4R,6R)-2,2-dimethyl-1,3-dioxane-4,6-diyl)bis(3-((tert-butyldiphenylsilyl)oxy)butan-1-ol)

There total 4 articles about (3R,3'R)-4,4'-((4R,6R)-2,2-dimethyl-1,3-dioxane-4,6-diyl)bis(3-((tert-butyldiphenylsilyl)oxy)butan-1-ol) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 1290537-65-3
C₅₆H₈₀O₈Si₂

: 1290537-63-1
(3R,3'R)-4,4'-((4R,6R)-2,2-dimethyl-1,3-dioxane-4,6-diyl)bis(3-((tert-butyldiphenylsilyl)oxy)butan-1-ol)

Guidance literature:: With diisobutylaluminium hydride; In tetrahydrofuran; toluene; at 0 - 25 ℃; Inert atmosphere;
DOI:10.1021/ol200735r

Reference yield:

: C₄₆H₆₀O₆Si₂

: 1290537-63-1
(3R,3'R)-4,4'-((4R,6R)-2,2-dimethyl-1,3-dioxane-4,6-diyl)bis(3-((tert-butyldiphenylsilyl)oxy)butan-1-ol)

Guidance literature:: With sodium tetrahydroborate; In methanol; dichloromethane; at -78 - 25 ℃; for 14h; Inert atmosphere;
DOI:10.1021/ol200735r

Reference yield:

: 1182723-08-5
(2R,2'R)-1,1'-((4S,6S)-dimethyl-1,3-dioxane-4,6-diyl)dipent-4-en-2-ol

: 1290537-63-1
(3R,3'R)-4,4'-((4R,6R)-2,2-dimethyl-1,3-dioxane-4,6-diyl)bis(3-((tert-butyldiphenylsilyl)oxy)butan-1-ol)

Guidance literature:: Multi-step reaction with 3 steps

1: 1H-imidazole / dichloromethane / 18 h / 25 °C / Inert atmosphere

2: ozone / methanol; dichloromethane / -78 °C / Inert atmosphere

3: sodium tetrahydroborate / methanol; dichloromethane / 14 h / -78 - 25 °C / Inert atmosphere

With 1H-imidazole; sodium tetrahydroborate; ozone; In methanol; dichloromethane;
DOI:10.1021/ol200735r