ethyl (2E)-4-bromo-4-{2-[3-(methoxymethyloxy)propyl]cyclohexylidene}-2-butenoate

Base Information

Chemical Name:ethyl (2E)-4-bromo-4-{2-[3-(methoxymethyloxy)propyl]cyclohexylidene}-2-butenoate
CAS No.:273936-78-0
Molecular Formula:C₁₇H₂₇BrO₄
Molecular Weight:375.303
Hs Code.:

Synonyms:ethyl (2E)-4-bromo-4-{2-[3-(methoxymethyloxy)propyl]cyclohexylidene}-2-butenoate

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Chemical Property of ethyl (2E)-4-bromo-4-{2-[3-(methoxymethyloxy)propyl]cyclohexylidene}-2-butenoate

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Technology Process of ethyl (2E)-4-bromo-4-{2-[3-(methoxymethyloxy)propyl]cyclohexylidene}-2-butenoate

There total 4 articles about ethyl (2E)-4-bromo-4-{2-[3-(methoxymethyloxy)propyl]cyclohexylidene}-2-butenoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2-(3-methoxymethoxy-propyl)-cyclohexanone

: 273936-78-0
ethyl (2E)-4-bromo-4-{2-[3-(methoxymethyloxy)propyl]cyclohexylidene}-2-butenoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: BuLi

2.1: 86 percent / DIBALH

3.1: Br₂-dioxane

3.2: pyridine

4.1: NaH

With n-butyllithium; dioxane dibromide; sodium hydride; diisobutylaluminium hydride; 1.1: Horner-Emmons olefination / 2.1: Reduction / 3.1: Bromination / 3.2: Dehydrobromination / 4.1: Horner-Emmons olefination;
DOI:10.1016/S0040-4039(99)02172-3

Reference yield:

: {2-[3-(methoxymethyloxy)propyl]cyclohexylidene}ethanal

: 273936-78-0
ethyl (2E)-4-bromo-4-{2-[3-(methoxymethyloxy)propyl]cyclohexylidene}-2-butenoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: Br₂-dioxane

1.2: pyridine

2.1: NaH

With dioxane dibromide; sodium hydride; 1.1: Bromination / 1.2: Dehydrobromination / 2.1: Horner-Emmons olefination;
DOI:10.1016/S0040-4039(99)02172-3

Reference yield:

: {2-[3-(methoxymethyloxy)propyl]cyclohexylidene}ethanenitrile

: 273936-78-0
ethyl (2E)-4-bromo-4-{2-[3-(methoxymethyloxy)propyl]cyclohexylidene}-2-butenoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: 86 percent / DIBALH

2.1: Br₂-dioxane

2.2: pyridine

3.1: NaH

With dioxane dibromide; sodium hydride; diisobutylaluminium hydride; 1.1: Reduction / 2.1: Bromination / 2.2: Dehydrobromination / 3.1: Horner-Emmons olefination;
DOI:10.1016/S0040-4039(99)02172-3