dimethyl 2-(2-(4-methyl-N-(3-phenylprop-2-yn-1-yl)phenylsulfonamido)phenyl)cyclopropane-1,1-dicarboxylate

Base Information

• Chemical Name: dimethyl 2-(2-(4-methyl-N-(3-phenylprop-2-yn-1-yl)phenylsulfonamido)phenyl)cyclopropane-1,1-dicarboxylate
• CAS No.: 1383545-87-6
• Molecular Formula: C₂₉H₂₇NO₆S
• Molecular Weight: 517.602
• Mol file: 1383545-87-6.mol

Synonyms:dimethyl 2-(2-(4-methyl-N-(3-phenylprop-2-yn-1-yl)phenylsulfonamido)phenyl)cyclopropane-1,1-dicarboxylate

Chemical Property of dimethyl 2-(2-(4-methyl-N-(3-phenylprop-2-yn-1-yl)phenylsulfonamido)phenyl)cyclopropane-1,1-dicarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of dimethyl 2-(2-(4-methyl-N-(3-phenylprop-2-yn-1-yl)phenylsulfonamido)phenyl)cyclopropane-1,1-dicarboxylate

There total 5 articles about dimethyl 2-(2-(4-methyl-N-(3-phenylprop-2-yn-1-yl)phenylsulfonamido)phenyl)cyclopropane-1,1-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C28H25NO6S + trimethylsulfoxonium iodide (1774-47-6) → dimethyl 2-(2-(4-methyl-N-(3-phenylprop-2-yn-1-yl)phenylsulfonamido)phenyl)cyclopropane-1,1-dicarboxylate (1383545-87-6)

Guidance literature:

With sodium hydride; In dimethyl sulfoxide; at 0 - 50 ℃; for 3h; Inert atmosphere;

DOI:10.1002/asia.201200104

Reference yield:

N-(2-formylphenyl)-4-methyl-N-(prop-2-yn-1-yl)benzenesulfonamide (1224713-12-5) → dimethyl 2-(2-(4-methyl-N-(3-phenylprop-2-yn-1-yl)phenylsulfonamido)phenyl)cyclopropane-1,1-dicarboxylate (1383545-87-6)

Guidance literature:

Multi-step reaction with 3 steps

1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / tetrahydrofuran / Inert atmosphere

2: piperidine / chloroform / Reflux

3: sodium hydride / dimethyl sulfoxide / 3 h / 0 - 50 °C / Inert atmosphere

With piperidine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; sodium hydride; triethylamine; In tetrahydrofuran; chloroform; dimethyl sulfoxide;

DOI:10.1002/asia.201200104

Reference yield:

N-(2-Formyl-phenyl)-4-methyl-benzenesulfonamide (6590-65-4) → dimethyl 2-(2-(4-methyl-N-(3-phenylprop-2-yn-1-yl)phenylsulfonamido)phenyl)cyclopropane-1,1-dicarboxylate (1383545-87-6)

Guidance literature:

Multi-step reaction with 4 steps

1: potassium carbonate / N,N-dimethyl-formamide / 15 h / 20 °C

2: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / tetrahydrofuran / Inert atmosphere

3: piperidine / chloroform / Reflux

4: sodium hydride / dimethyl sulfoxide / 3 h / 0 - 50 °C / Inert atmosphere

With piperidine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; sodium hydride; potassium carbonate; triethylamine; In tetrahydrofuran; chloroform; dimethyl sulfoxide; N,N-dimethyl-formamide;

DOI:10.1002/asia.201200104

upstream raw materials:

N-(3-phenyl-prop-2-ynyl)-N-(2-formyl-phenyl)-4-methyl-benzenesulfonamide

N-(2-formylphenyl)-4-methyl-N-(prop-2-yn-1-yl)benzenesulfonamide

trimethylsulfoxonium iodide

iodobenzene

Downstream raw materials:

dimethyl 3-phenyl-5-tosyl-4,5-dihydro-1H-cyclopenta[c]quinoline-2,2(9bH)-dicarboxylate