1-(4-((2-fluoro-6-methoxy-3'-nitro-[1,1'-biphenyl]-3-yl)methyl)phenyl)urea

Base Information

Chemical Name:1-(4-((2-fluoro-6-methoxy-3'-nitro-[1,1'-biphenyl]-3-yl)methyl)phenyl)urea
CAS No.:1158231-00-5
Molecular Formula:C₂₁H₁₈FN₃O₄
Molecular Weight:395.39
Hs Code.:

Synonyms:1-(4-((2-fluoro-6-methoxy-3'-nitro-[1,1'-biphenyl]-3-yl)methyl)phenyl)urea

Suppliers and Price of 1-(4-((2-fluoro-6-methoxy-3'-nitro-[1,1'-biphenyl]-3-yl)methyl)phenyl)urea

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-(4-((2-fluoro-6-methoxy-3'-nitro-[1,1'-biphenyl]-3-yl)methyl)phenyl)urea

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 1-(4-((2-fluoro-6-methoxy-3'-nitro-[1,1'-biphenyl]-3-yl)methyl)phenyl)urea

There total 5 articles about 1-(4-((2-fluoro-6-methoxy-3'-nitro-[1,1'-biphenyl]-3-yl)methyl)phenyl)urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 1431572-20-1
1-(4-(3-bromo-2-fluoro-4-methoxybenzyl)phenyl)urea

: 13331-27-6
m-nitrobenzene boronic acid

: 1158231-00-5
1-(4-((2-fluoro-6-methoxy-3'-nitro-[1,1'-biphenyl]-3-yl)methyl)phenyl)urea

Guidance literature:: With potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; ethanol; water; at 80 ℃; for 17h; Inert atmosphere;
DOI:10.1016/j.tetlet.2013.03.063

Reference yield:

: 1155877-70-5
3-bromo-2-fluoro-4-methoxybenzaldehyde

: 1158231-00-5
1-(4-((2-fluoro-6-methoxy-3'-nitro-[1,1'-biphenyl]-3-yl)methyl)phenyl)urea

Guidance literature:: Multi-step reaction with 4 steps

1: sodium tetrahydroborate / tetrahydrofuran; water / 3.5 h / 0 - 20 °C

2: N-Bromosuccinimide; triphenylphosphine / dichloromethane / 2 h / 0 °C

3: potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; ethanol; 1,2-dimethoxyethane / 4 h / 60 °C

4: potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; ethanol; 1,2-dimethoxyethane / 17 h / 80 °C / Inert atmosphere

With sodium tetrahydroborate; potassium phosphate; N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triphenylphosphine; In tetrahydrofuran; 1,2-dimethoxyethane; ethanol; dichloromethane; water; 3: |Suzuki Coupling / 4: |Suzuki Coupling;
DOI:10.1016/j.tetlet.2013.03.063

Reference yield:

: 446-59-3
2‐bromo‐1‐fluoro‐3‐methoxybenzene

: 1158231-00-5
1-(4-((2-fluoro-6-methoxy-3'-nitro-[1,1'-biphenyl]-3-yl)methyl)phenyl)urea

Guidance literature:: Multi-step reaction with 5 steps

1: titanium tetrachloride / dichloromethane / 2 h / Cooling with ice; Inert atmosphere

2: sodium tetrahydroborate / tetrahydrofuran; water / 3.5 h / 0 - 20 °C

3: N-Bromosuccinimide; triphenylphosphine / dichloromethane / 2 h / 0 °C

4: potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; ethanol; 1,2-dimethoxyethane / 4 h / 60 °C

5: potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; ethanol; 1,2-dimethoxyethane / 17 h / 80 °C / Inert atmosphere

With sodium tetrahydroborate; potassium phosphate; N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; titanium tetrachloride; triphenylphosphine; In tetrahydrofuran; 1,2-dimethoxyethane; ethanol; dichloromethane; water; 4: |Suzuki Coupling / 5: |Suzuki Coupling;
DOI:10.1016/j.tetlet.2013.03.063