Technology Process of (4-((1R,3aS,5aR,5bR,7aR,11aS,11bR,13aR,13bR)-3a-((benzyloxy)carbonyl)-5a,5b,8,8,11a-pentamethyl-1-(prop-1-en-2-yl)-2,3,3a,4,5,5a,5b,6,7,7a,8,11,11a,11b,12,13,13a,13b-octadecahydro-1H-cyclopenta[a]chrysen-9-yl)phenyl)boronic acid
There total 5 articles about (4-((1R,3aS,5aR,5bR,7aR,11aS,11bR,13aR,13bR)-3a-((benzyloxy)carbonyl)-5a,5b,8,8,11a-pentamethyl-1-(prop-1-en-2-yl)-2,3,3a,4,5,5a,5b,6,7,7a,8,11,11a,11b,12,13,13a,13b-octadecahydro-1H-cyclopenta[a]chrysen-9-yl)phenyl)boronic acid which
guide to synthetic route it.
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synthetic route:
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![(1R,3aS,5aR,5bR,7aR,11aR,11bR,13aR,13bR)-benzyl 5a,5b,8,8,11a-pentamethyl-1-(prop-1-en-2-yl)-9-(((trifluoromethyl)sulfonyl)oxy)-2,3,3a,4,5,5a,5b,6,7,7a,8,11,11a,11b,12,13,13a,13b-octadecahydro-1H-cyclopenta[a]chrysene-3a-carboxylate](/Databaselist/images/loading.webp)
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1350915-20-6
(1R,3aS,5aR,5bR,7aR,11aR,11bR,13aR,13bR)-benzyl 5a,5b,8,8,11a-pentamethyl-1-(prop-1-en-2-yl)-9-(((trifluoromethyl)sulfonyl)oxy)-2,3,3a,4,5,5a,5b,6,7,7a,8,11,11a,11b,12,13,13a,13b-octadecahydro-1H-cyclopenta[a]chrysene-3a-carboxylate
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1350915-35-3
(4-((1R,3aS,5aR,5bR,7aR,11aS,11bR,13aR,13bR)-3a-((benzyloxy)carbonyl)-5a,5b,8,8,11a-pentamethyl-1-(prop-1-en-2-yl)-2,3,3a,4,5,5a,5b,6,7,7a,8,11,11a,11b,12,13,13a,13b-octadecahydro-1H-cyclopenta[a]chrysen-9-yl)phenyl)boronic acid
- Guidance literature:
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With
sodium carbonate;
In
tetrahydrofuran; water;
at 90 ℃;
for 6h;
Inert atmosphere;
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1350915-35-3
(4-((1R,3aS,5aR,5bR,7aR,11aS,11bR,13aR,13bR)-3a-((benzyloxy)carbonyl)-5a,5b,8,8,11a-pentamethyl-1-(prop-1-en-2-yl)-2,3,3a,4,5,5a,5b,6,7,7a,8,11,11a,11b,12,13,13a,13b-octadecahydro-1H-cyclopenta[a]chrysen-9-yl)phenyl)boronic acid
- Guidance literature:
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Multi-step reaction with 4 steps
1: potassium carbonate / N,N-dimethyl-formamide / 3.5 h / 60 °C / Inert atmosphere
2: pyridinium chlorochromate / dichloromethane / 5.5 h / Inert atmosphere
3: potassium hexamethylsilazane / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere
4: sodium carbonate / water; tetrahydrofuran / 6 h / 90 °C / Inert atmosphere
With
potassium hexamethylsilazane; sodium carbonate; potassium carbonate; pyridinium chlorochromate;
In
tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide;
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1350915-35-3
(4-((1R,3aS,5aR,5bR,7aR,11aS,11bR,13aR,13bR)-3a-((benzyloxy)carbonyl)-5a,5b,8,8,11a-pentamethyl-1-(prop-1-en-2-yl)-2,3,3a,4,5,5a,5b,6,7,7a,8,11,11a,11b,12,13,13a,13b-octadecahydro-1H-cyclopenta[a]chrysen-9-yl)phenyl)boronic acid
- Guidance literature:
-
Multi-step reaction with 4 steps
1: potassium carbonate / N,N-dimethyl-formamide / 3.5 h / 60 °C / Inert atmosphere
2: pyridinium chlorochromate / dichloromethane / 5.5 h / Inert atmosphere
3: potassium hexamethylsilazane / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere
4: sodium carbonate / water; tetrahydrofuran / 6 h / 90 °C / Inert atmosphere
With
potassium hexamethylsilazane; sodium carbonate; potassium carbonate; pyridinium chlorochromate;
In
tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide;
