2-methyl-2-[4-{[(4-methyl-2-[4-trifluoromethoxyphenyl]-thiazol-5-ylcarbonyl)amino]methyl}phenoxy]propionic acid ethyl ester

Base Information

Chemical Name:2-methyl-2-[4-{[(4-methyl-2-[4-trifluoromethoxyphenyl]-thiazol-5-ylcarbonyl)amino]methyl}phenoxy]propionic acid ethyl ester
CAS No.:343322-26-9
Molecular Formula:C₂₅H₂₅F₃N₂O₅S
Molecular Weight:522.545
Hs Code.:

Synonyms:2-methyl-2-[4-{[(4-methyl-2-[4-trifluoromethoxyphenyl]-thiazol-5-ylcarbonyl)amino]methyl}phenoxy]propionic acid ethyl ester

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Chemical Property of 2-methyl-2-[4-{[(4-methyl-2-[4-trifluoromethoxyphenyl]-thiazol-5-ylcarbonyl)amino]methyl}phenoxy]propionic acid ethyl ester

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Technology Process of 2-methyl-2-[4-{[(4-methyl-2-[4-trifluoromethoxyphenyl]-thiazol-5-ylcarbonyl)amino]methyl}phenoxy]propionic acid ethyl ester

There total 7 articles about 2-methyl-2-[4-{[(4-methyl-2-[4-trifluoromethoxyphenyl]-thiazol-5-ylcarbonyl)amino]methyl}phenoxy]propionic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 55458-83-8
ethyl 2-{[4-(aminomethyl)phenyl]oxy}-2-methylpropanoate

: 187998-69-2
4-methyl-2-{4-[(trifluoromethyl)oxy]phenyl}-1,3-thiazole-5-carboxylic acid

: 343322-26-9
2-methyl-2-[4-{[(4-methyl-2-[4-trifluoromethoxyphenyl]-thiazol-5-ylcarbonyl)amino]methyl}phenoxy]propionic acid ethyl ester

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 18h;
DOI:10.1021/jm058056x

Reference yield: 41.0%

: 343322-26-9
2-methyl-2-[4-{[(4-methyl-2-[4-trifluoromethoxyphenyl]-thiazol-5-ylcarbonyl)amino]methyl}phenoxy]propionic acid ethyl ester

Guidance literature:

Reference yield:

: 600-00-0
ethyl 2-bromoisobutyrate

: 343322-26-9
2-methyl-2-[4-{[(4-methyl-2-[4-trifluoromethoxyphenyl]-thiazol-5-ylcarbonyl)amino]methyl}phenoxy]propionic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: NaH / dimethylformamide / 0.5 h / 20 °C

1.2: dimethylformamide / 20 - 80 °C

2.1: H₂; AcOH / Pd/C / ethanol / 8 h / 20 °C / 1500.12 Torr

3.1: 69 percent / HOBT; EDCI; Et₃N / dimethylformamide / 18 h / 20 °C

With hydrogen; sodium hydride; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; palladium on activated charcoal; In ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm058056x