ethyl 4-methyl-2-{4-[(trifluoromethyl)oxy]phenyl}-1,3-thiazole-5-carboxylate

Base Information

Chemical Name:ethyl 4-methyl-2-{4-[(trifluoromethyl)oxy]phenyl}-1,3-thiazole-5-carboxylate
CAS No.:343322-56-5
Molecular Formula:C₁₄H₁₂F₃NO₃S
Molecular Weight:331.315
Hs Code.:

Synonyms:ethyl 4-methyl-2-{4-[(trifluoromethyl)oxy]phenyl}-1,3-thiazole-5-carboxylate

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Chemical Property of ethyl 4-methyl-2-{4-[(trifluoromethyl)oxy]phenyl}-1,3-thiazole-5-carboxylate

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Technology Process of ethyl 4-methyl-2-{4-[(trifluoromethyl)oxy]phenyl}-1,3-thiazole-5-carboxylate

There total 1 articles about ethyl 4-methyl-2-{4-[(trifluoromethyl)oxy]phenyl}-1,3-thiazole-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 149169-34-6
4-trifluoromethoxy-thiobenzamide

: 609-15-4
ethyl 2-chloro-3-oxo-butyrate

: 343322-56-5
ethyl 4-methyl-2-{4-[(trifluoromethyl)oxy]phenyl}-1,3-thiazole-5-carboxylate

Guidance literature:: In ethanol; for 24h; Heating;
DOI:10.1021/jm058056x

Reference yield: 66.0%

: 343322-56-5
ethyl 4-methyl-2-{4-[(trifluoromethyl)oxy]phenyl}-1,3-thiazole-5-carboxylate

: 187998-69-2
4-methyl-2-{4-[(trifluoromethyl)oxy]phenyl}-1,3-thiazole-5-carboxylic acid

Guidance literature:: With sodium hydroxide; In ethanol; water; at 85 ℃; for 1.5h;
DOI:10.1021/jm058056x

Reference yield:

: 343322-56-5
ethyl 4-methyl-2-{4-[(trifluoromethyl)oxy]phenyl}-1,3-thiazole-5-carboxylate

: 2-methyl-2-[4-{[(4-methyl-2-[4-trifluoromethoxyphenyl]thiazol-5-ylcarbonyl)amino]methyl}phenoxy]propionic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 66 percent / NaOH / ethanol; H₂O / 1.5 h / 85 °C

2: 69 percent / HOBT; EDCI; Et₃N / dimethylformamide / 18 h / 20 °C

3: 45 percent / aq. NaOH / tetrahydrofuran / 18 h / Heating

With sodium hydroxide; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide;
DOI:10.1021/jm058056x