4-Methyl-2-[4-(trifluoromethoxy)phenyl]-1,3-thiazole-5-carboxylic acid

Base Information

Chemical Name:4-Methyl-2-[4-(trifluoromethoxy)phenyl]-1,3-thiazole-5-carboxylic acid
CAS No.:187998-69-2
Molecular Formula:C₁₂H₈F₃NO₃S
Molecular Weight:303.262
Hs Code.:
Mol file:187998-69-2.mol

Synonyms:4-methyl-2-{4-[(trifluoromethyl)oxy]phenyl}-1,3-thiazole-5-carboxylic acid

Suppliers and Price of 4-Methyl-2-[4-(trifluoromethoxy)phenyl]-1,3-thiazole-5-carboxylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
4-METHYL-2-(4-(TRIFLUOROMETHOXY)PHENYL)THIAZOLE-5-CARBOXYLIC ACID 95.00%
5MG
$ 501.86

A1 Biochem Labs
4-Methyl-2-(4-(trifluoromethoxy)phenyl)thiazole-5-carboxylicacid 95%
5 g
$ 1150.00

Total 1 raw suppliers

Chemical Property of 4-Methyl-2-[4-(trifluoromethoxy)phenyl]-1,3-thiazole-5-carboxylic acid

Chemical Property:

Purity/Quality:: 4-METHYL-2-(4-(TRIFLUOROMETHOXY)PHENYL)THIAZOLE-5-CARBOXYLIC ACID 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 4-Methyl-2-[4-(trifluoromethoxy)phenyl]-1,3-thiazole-5-carboxylic acid

There total 2 articles about 4-Methyl-2-[4-(trifluoromethoxy)phenyl]-1,3-thiazole-5-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 343322-56-5
ethyl 4-methyl-2-{4-[(trifluoromethyl)oxy]phenyl}-1,3-thiazole-5-carboxylate

: 187998-69-2
4-methyl-2-{4-[(trifluoromethyl)oxy]phenyl}-1,3-thiazole-5-carboxylic acid

Guidance literature:: With sodium hydroxide; In ethanol; water; at 85 ℃; for 1.5h;
DOI:10.1021/jm058056x

Reference yield:

: 149169-34-6
4-trifluoromethoxy-thiobenzamide

: 187998-69-2
4-methyl-2-{4-[(trifluoromethyl)oxy]phenyl}-1,3-thiazole-5-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: ethanol / 24 h / Heating

2: 66 percent / NaOH / ethanol; H₂O / 1.5 h / 85 °C

With sodium hydroxide; In ethanol; water;
DOI:10.1021/jm058056x

Reference yield: 69.0%

: 55458-83-8
ethyl 2-{[4-(aminomethyl)phenyl]oxy}-2-methylpropanoate

: 187998-69-2
4-methyl-2-{4-[(trifluoromethyl)oxy]phenyl}-1,3-thiazole-5-carboxylic acid

: 343322-26-9
2-methyl-2-[4-{[(4-methyl-2-[4-trifluoromethoxyphenyl]-thiazol-5-ylcarbonyl)amino]methyl}phenoxy]propionic acid ethyl ester

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 18h;
DOI:10.1021/jm058056x