3-{(5S,6R)-5-[4-(2,3-Dihydroxy-propoxy)-phenyl]-6-phenyl-5,6,7,8-tetrahydro-naphthalen-2-yloxy}-propane-1,2-diol

Base Information

• Chemical Name: 3-{(5S,6R)-5-[4-(2,3-Dihydroxy-propoxy)-phenyl]-6-phenyl-5,6,7,8-tetrahydro-naphthalen-2-yloxy}-propane-1,2-diol
• CAS No.: 72105-64-7
• Molecular Formula: C₂₈H₃₂O₆
• Molecular Weight: 464.558

Synonyms:3-{(5S,6R)-5-[4-(2,3-Dihydroxy-propoxy)-phenyl]-6-phenyl-5,6,7,8-tetrahydro-naphthalen-2-yloxy}-propane-1,2-diol

Chemical Property of 3-{(5S,6R)-5-[4-(2,3-Dihydroxy-propoxy)-phenyl]-6-phenyl-5,6,7,8-tetrahydro-naphthalen-2-yloxy}-propane-1,2-diol

Chemical Property:

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Technology Process of 3-{(5S,6R)-5-[4-(2,3-Dihydroxy-propoxy)-phenyl]-6-phenyl-5,6,7,8-tetrahydro-naphthalen-2-yloxy}-propane-1,2-diol

There total 3 articles about 3-{(5S,6R)-5-[4-(2,3-Dihydroxy-propoxy)-phenyl]-6-phenyl-5,6,7,8-tetrahydro-naphthalen-2-yloxy}-propane-1,2-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-(p-hydroxyphenyl)-6-methoxy-2-phenyl-3,4-dihydronaphthalene (1729-38-0) → 3-{(5S,6R)-5-[4-(2,3-Dihydroxy-propoxy)-phenyl]-6-phenyl-5,6,7,8-tetrahydro-naphthalen-2-yloxy}-propane-1,2-diol (72105-64-7)

Guidance literature:

Multi-step reaction with 3 steps

1: H₂ / Pd-C / acetic acid

2: (i) NaOEt, EtOH, (ii) 3-iodo-propane-1,2-diol, (iii) BBr₃, CH₂Cl₂

3: (i) NaOEt, EtOH, (ii) /BRN= 1732048/

With hydrogen; palladium on activated charcoal; In acetic acid;

DOI:10.1021/jm00198a015

Reference yield:

4-(cis-6-methoxy-2-phenyltetralin-1-yl)phenol (5879-91-4,14089-22-6,14810-55-0,72105-59-0) → 3-{(5S,6R)-5-[4-(2,3-Dihydroxy-propoxy)-phenyl]-6-phenyl-5,6,7,8-tetrahydro-naphthalen-2-yloxy}-propane-1,2-diol (72105-64-7)

Guidance literature:

Multi-step reaction with 2 steps

1: (i) NaOEt, EtOH, (ii) 3-iodo-propane-1,2-diol, (iii) BBr₃, CH₂Cl₂

2: (i) NaOEt, EtOH, (ii) /BRN= 1732048/

DOI:10.1021/jm00198a015

Reference yield:

3-iodo-propane-1,2-diol (554-10-9) + (5S,6R)-5-(4-Hydroxy-phenyl)-6-phenyl-5,6,7,8-tetrahydro-naphthalen-2-ol (72105-62-5) → 3-{(5S,6R)-5-[4-(2,3-Dihydroxy-propoxy)-phenyl]-6-phenyl-5,6,7,8-tetrahydro-naphthalen-2-yloxy}-propane-1,2-diol (72105-64-7)

Guidance literature:

Multistep reaction; (i) NaOEt, EtOH, (ii) /BRN= 1732048/;

DOI:10.1021/jm00198a015

upstream raw materials:

3-iodo-propane-1,2-diol

(5S,6R)-5-(4-Hydroxy-phenyl)-6-phenyl-5,6,7,8-tetrahydro-naphthalen-2-ol

1-(p-hydroxyphenyl)-6-methoxy-2-phenyl-3,4-dihydronaphthalene

4-(cis-6-methoxy-2-phenyltetralin-1-yl)phenol

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