1729-38-0

Usage

InChI:InChI=1/C23H20O2/c1-25-20-12-14-22-18(15-20)9-13-21(16-5-3-2-4-6-16)23(22)17-7-10-19(24)11-8-17/h2-8,10-12,14-15,24H,9,13H2,1H3

Upstream product

• 17878-44-3 (4-bromophenoxy)trimethylsilane 
• 1769-84-2 6-methoxy-2-phenyl-1-tetralone 
• 1078-19-9 6-methoxy-3,4-dihydro-1(2H)-naphthalenone 
• 71597-85-8 (p-hydroxyphenyl)boronic acid 
• 945421-08-9 7-methoxy-3-phenyl-4-(4-pivaloyloxyphenyl)-3,4-dihydronaphthalene 
• 586-37-8 1-(3-Methoxyphenyl)ethanone 
• 1729-34-6 2-Phenyl-4-(3-methoxyphenyl)-4-ketobuttersaeure 
• 1729-33-5 2-Phenyl-4-(3-methoxyphenyl)-4-ketobutyronitril 
• 22966-24-1 1-(3-methoxyphenyl)-3-phenyl-2-propene-1-one 

Downstream Products

• 4310-64-9 1-[p-(2,3-Dihydroxypropoxy)phenyl]-2-phenyl-6-methoxy-3,4-dihydronaphthalin 
• 5879-91-4 4-(cis-6-methoxy-2-phenyltetralin-1-yl)phenol 
• 72105-58-9 4-((1S,2S)-2-Cyclohexyl-6-methoxy-1,2,3,4-tetrahydro-naphthalen-1-yl)-phenol 
• 5879-91-4 4-(6-methoxy-2-phenyl-1,2,3,4-tetrahydronaphthalen-1-yl)phenol 
• 72105-64-7 3-{(5S,6R)-5-[4-(2,3-Dihydroxy-propoxy)-phenyl]-6-phenyl-5,6,7,8-tetrahydro-naphthalen-2-yloxy}-propane-1,2-diol 
• 22845-55-2 U₂₃₄₆₉ 
• 72105-61-4 3-[4-((1S,2R)-6-Hydroxy-2-phenyl-1,2,3,4-tetrahydro-naphthalen-1-yl)-phenoxy]-propane-1,2-diol 
• 72105-62-5 (5S,6R)-5-(4-Hydroxy-phenyl)-6-phenyl-5,6,7,8-tetrahydro-naphthalen-2-ol 
• 180915-78-0 lasofoxifene 
• 1845-11-0 nafoxidine 

Relevant academic research and scientific papers

An expeditious synthesis of lasofoxifene and nafoxidine via the novel three-component coupling reaction

The simple and efficient synthesis of lasofoxifene (4), a possible candidate for alleviating osteoporosis, via the novel three-component coupling reaction among 4-pivaloyloxybenzaldehyde (5), cinnamyltrimethylsilane (6), and anisole in the presence of HfCl4 is illustrated. The successive cationic cyclization of the coupling product, olefin formation, and migration of the double-bond are performed to afford the common synthetic intermediate of lasofoxifene (4) and nafoxidine (3) via a very concise procedure. Copyright

TETRAHYDRONAPHTHALENE ESTROGEN RECEPTOR MODULATORS AND USES THEREOF

Described herein are tetrahydronaphthalene compounds with estrogen receptor modulation activity or function having the Formula I structure: and stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, and with the substituents and structura

NOVEL DIHYDRONAPHTHALENE COMPOUND AND USE THEREOF

Disclosed is a compound represented by the formula (I) below as a dihydronaphthalene compound having a chemical structure which is excellent in production efficiency when compared with lasofoxifene and nafoxidine. This compound is useful as a proteasome i

Synthesis of lasofoxifene, nafoxidine and their positional isomers via the novel three-component coupling reaction

A Lewis acid-mediated three-component coupling reaction was successfully applied for the synthesis of lasofoxifene (1), nafoxidine (2), and their positional isomers, inv-lasofoxifene (3) and inv-nafoxidine (4). In the presence of HfCl4, the des

PROCESS FOR PRODUCTION OF LASOFOXIFENE OR ANALOGUE THEREOF

Disclosed is a novel process for production of lasofoxifene, nafoxidine or an analogue thereof, which comprises reduced number of reaction steps, has a high efficiency, and is practically advantageous. For the production of lasofoxifene or an analogue the

Compounds and process for preparing the same

Cis and trans isomers of 1,2-diphenyl-1,2,3,4-tetrahydronaphthalenes, novel processes for the preparation thereof, and novel intermediates are disclosed herein. The novel 1,2-diphenyl-1,2,3,4-tetrahydronaphthalenes have utility as antifertility estrogenic, anti-estrogenic, anti-spermatogenic, cholesterol lowering and lipid normalizing agents.