554-10-9Relevant articles and documents
Amino acid ionic liquids as catalysts in a solvent-free Morita-Baylis-Hillman reaction
Pereira, Mathias Prado,Souza Martins, Rafaela De,De Oliveira, Marcone Augusto Leal,Bombonato, Fernanda Irene
, p. 23903 - 23913 (2018/07/13)
In the present work, we describe the preparation of ten amino acid ionic liquids (AAILs) formed from ammonium salts as cations, derivatives of glycerol, and natural amino acids as anions. All of them are viscous oils, colorless or pale yellow, and hygroscopic at room temperature. They have appreciable solubility in many protic and aprotic polar solvents. The AAILs were used as catalysts in a Morita-Baylis-Hillman (MBH) reaction. The ionic liquids derivative from l-proline and l-histidine demonstrated the ability to catalyze the reaction between methyl vinyl ketone and aromatic aldehydes differently substituted in the absence of an additional co-catalyst under organic solvent-free conditions. The AAIL derivatives from l-valine, l-leucine, and l-tyrosine catalyzed the MBH reaction only in the presence of imidazole. The MBH adducts were obtained in moderate to good yields. Although the catalytic site in the ILs was in its enantiomerically pure form, all the MBH adducts were obtained in their racemic form.
Pharmaceutical compositions containing 3-IODO-1,2-propanediol having mucolytic activity
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, (2008/06/13)
The present invention relates to pharmaceutical compositions containing 3-iodo-1,2-propanediol which are effective in increasing the output of thin respiratory tract fluid and liquefying tenacious mucus in the bronchial tree.
Glycerin esters of some higher fatty acids as pharmaceutic aids. II. Preparation of diester and triester
Chalabala,Lichnerova,Starha,Lukas
, p. 277 - 278 (2007/10/05)
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