N-(5-(3-benzyl-1-(4-cyanophenyl)-3H-pyrazolo[3,4-c]quinolin-8-yl)pyridin-3-yl)acetamide

Base Information

Chemical Name:N-(5-(3-benzyl-1-(4-cyanophenyl)-3H-pyrazolo[3,4-c]quinolin-8-yl)pyridin-3-yl)acetamide
CAS No.:1201646-60-7
Molecular Formula:C₃₁H₂₂N₆O
Molecular Weight:494.555
Hs Code.:

Synonyms:N-(5-(3-benzyl-1-(4-cyanophenyl)-3H-pyrazolo[3,4-c]quinolin-8-yl)pyridin-3-yl)acetamide

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Chemical Property of N-(5-(3-benzyl-1-(4-cyanophenyl)-3H-pyrazolo[3,4-c]quinolin-8-yl)pyridin-3-yl)acetamide

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Technology Process of N-(5-(3-benzyl-1-(4-cyanophenyl)-3H-pyrazolo[3,4-c]quinolin-8-yl)pyridin-3-yl)acetamide

There total 16 articles about N-(5-(3-benzyl-1-(4-cyanophenyl)-3H-pyrazolo[3,4-c]quinolin-8-yl)pyridin-3-yl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 1201646-58-3
N-(5-(3-benzyl-1-bromo-3H-pyrazolo[3,4-c]quinolin-8-yl)pyridin-3-yl)acetamide

: 126747-14-6
4-cyanophenylboronic acid

: 1201646-60-7
N-(5-(3-benzyl-1-(4-cyanophenyl)-3H-pyrazolo[3,4-c]quinolin-8-yl)pyridin-3-yl)acetamide

Guidance literature:: With potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In N,N-dimethyl-formamide; at 155 ℃; for 8h; Inert atmosphere;

Reference yield:

: 723281-72-9
6-bromo-4-chloro-3-nitroquinoline

: 1201646-60-7
N-(5-(3-benzyl-1-(4-cyanophenyl)-3H-pyrazolo[3,4-c]quinolin-8-yl)pyridin-3-yl)acetamide

Guidance literature:: Multi-step reaction with 11 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 80 °C

1.2: 20 °C

2.1: hydrogenchloride; water / Reflux

3.1: iron; acetic acid / 0.5 h / 20 °C

4.1: potassium acetate / toluene / 2 h / 60 °C

4.2: 8 h / 85 °C / Inert atmosphere

5.1: methanol; potassium carbonate / 2 h / Reflux

6.1: ethanol / 2 h / Reflux

7.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 8 h / 155 °C / Inert atmosphere

8.1: potassium tert-butylate; oxygen; dimethyl sulfoxide / tetrahydrofuran / 0.17 h / 20 °C

9.1: N-Bromosuccinimide / acetonitrile / 0.5 h / Reflux

10.1: potassium carbonate / ethanol / 2 h / Reflux

11.1: potassium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide / 8 h / 155 °C / Inert atmosphere

With hydrogenchloride; methanol; N-Bromosuccinimide; potassium tert-butylate; water; oxygen; potassium acetate; iron; sodium hydride; potassium carbonate; acetic acid; dimethyl sulfoxide; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide; toluene; acetonitrile;

Reference yield:

: 15862-46-1
N-(5-bromo-pyridin-3-yl)-acetamide

: 1201646-60-7
N-(5-(3-benzyl-1-(4-cyanophenyl)-3H-pyrazolo[3,4-c]quinolin-8-yl)pyridin-3-yl)acetamide

Guidance literature:: Multi-step reaction with 6 steps

1: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 8 h / 85 °C / Inert atmosphere

2: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 8 h / 155 °C / Inert atmosphere

3: potassium tert-butylate; oxygen; dimethyl sulfoxide / tetrahydrofuran / 0.17 h / 20 °C

4: N-Bromosuccinimide / acetonitrile / 0.5 h / Reflux

5: potassium carbonate / ethanol / 2 h / Reflux

6: potassium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide / 8 h / 155 °C / Inert atmosphere

With N-Bromosuccinimide; potassium tert-butylate; oxygen; potassium acetate; potassium carbonate; dimethyl sulfoxide; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; ethanol; N,N-dimethyl-formamide; acetonitrile;