(E)-4-{3-[4-(4-bromophenyl)-2-oxo-1,2-dihydroquinolin-3-yl]-5-(4-chlorophenyl)-4,5-dihydro-1H-pyrazol-1-yl}-4-oxobut-2-enoic acid

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Chemical Name:(E)-4-{3-[4-(4-bromophenyl)-2-oxo-1,2-dihydroquinolin-3-yl]-5-(4-chlorophenyl)-4,5-dihydro-1H-pyrazol-1-yl}-4-oxobut-2-enoic acid
CAS No.:1449374-30-4
Molecular Formula:C₂₈H₁₉BrClN₃O₄
Molecular Weight:576.834
Hs Code.:

Synonyms:(E)-4-{3-[4-(4-bromophenyl)-2-oxo-1,2-dihydroquinolin-3-yl]-5-(4-chlorophenyl)-4,5-dihydro-1H-pyrazol-1-yl}-4-oxobut-2-enoic acid

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Chemical Property of (E)-4-{3-[4-(4-bromophenyl)-2-oxo-1,2-dihydroquinolin-3-yl]-5-(4-chlorophenyl)-4,5-dihydro-1H-pyrazol-1-yl}-4-oxobut-2-enoic acid

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Technology Process of (E)-4-{3-[4-(4-bromophenyl)-2-oxo-1,2-dihydroquinolin-3-yl]-5-(4-chlorophenyl)-4,5-dihydro-1H-pyrazol-1-yl}-4-oxobut-2-enoic acid

There total 5 articles about (E)-4-{3-[4-(4-bromophenyl)-2-oxo-1,2-dihydroquinolin-3-yl]-5-(4-chlorophenyl)-4,5-dihydro-1H-pyrazol-1-yl}-4-oxobut-2-enoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 1449374-33-7
(E)-methyl 4-{3-[4-(4-bromophenyl)-2-oxo-1,2-dihydroquinolin-3-yl]-5-(4-chlorophenyl)-4,5-dihydro-1H-pyrazol-1-yl}-4-oxobut-2-enoate

: 1449374-30-4
(E)-4-{3-[4-(4-bromophenyl)-2-oxo-1,2-dihydroquinolin-3-yl]-5-(4-chlorophenyl)-4,5-dihydro-1H-pyrazol-1-yl}-4-oxobut-2-enoic acid

Guidance literature:: (E)-methyl 4-{3-[4-(4-bromophenyl)-2-oxo-1,2-dihydroquinolin-3-yl]-5-(4-chlorophenyl)-4,5-dihydro-1H-pyrazol-1-yl}-4-oxobut-2-enoate; With sodium hydroxide; In ethanol; for 4h;

With hydrogenchloride; In ethanol; water;

Reference yield:

: 1449373-54-9
4-(4-bromophenyl)-3-[5-(4-chlorophenyl)-4,5-dihydro-1H-pyrazol-3-yl]quinolin-2(1H)-one

: 1449374-30-4
(E)-4-{3-[4-(4-bromophenyl)-2-oxo-1,2-dihydroquinolin-3-yl]-5-(4-chlorophenyl)-4,5-dihydro-1H-pyrazol-1-yl}-4-oxobut-2-enoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: tetrahydrofuran / 0.33 h / 165 °C / Microwave irradiation; Molecular sieve

2: sodium hydroxide / water; ethanol / 4 h

With sodium hydroxide; In tetrahydrofuran; ethanol; water;
DOI:10.1021/jm400652r

Reference yield:

: 1140-17-6
2-amino-4'-bromobenzophenone

: 1449374-30-4
(E)-4-{3-[4-(4-bromophenyl)-2-oxo-1,2-dihydroquinolin-3-yl]-5-(4-chlorophenyl)-4,5-dihydro-1H-pyrazol-1-yl}-4-oxobut-2-enoic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: N,N-dimethyl-formamide / 1.25 h / 140 °C / Microwave irradiation; Molecular sieve

2.1: potassium hydroxide / water; ethanol / 0.75 h / 0 °C

2.2: 0 - 20 °C

3.1: hydrazine / ethanol / 0.33 h / 110 °C / Microwave irradiation

4.1: tetrahydrofuran / 0.33 h / 165 °C / Microwave irradiation; Molecular sieve

5.1: sodium hydroxide / water; ethanol / 4 h

With potassium hydroxide; sodium hydroxide; hydrazine; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide;
DOI:10.1021/jm400652r