2-Amino-4'-bromobenzophenone

Base Information

• Chemical Name: 2-Amino-4'-bromobenzophenone
• CAS No.: 1140-17-6
• Molecular Formula: C13H10 Br N O
• Molecular Weight: 276.132
• Hs Code.: 2922399090
• European Community (EC) Number: 628-416-3
• DSSTox Substance ID: DTXSID70412777
• Nikkaji Number: J3.082.715E
• Wikidata: Q72440505
• Mol file: 1140-17-6.mol

Synonyms:2-amino-4'-bromobenzophenone;1140-17-6;(2-Aminophenyl)(4-bromophenyl)methanone;Methanone, (2-aminophenyl)(4-bromophenyl)-;(2-aminophenyl)-(4-bromophenyl)methanone;2-Amino-4/'-bromobenzophenone;MFCD02181034;2-(4-bromobenzoyl)aniline;Methanone,(2-aminophenyl)(4-bromophenyl)-;(2-AMINO-PHENYL)-(4-BROMO-PHENYL)METHANONE;SCHEMBL141641;DTXSID70412777;WIISOMGJWLLMDG-UHFFFAOYSA-N;2-Amino-4'-bromobenzophenone, 95%;AKOS013602943;CS-W008171;AS-15451;SY030194;AM20060488;FT-0601237;A852576;J-003048;2-Amino-4 inverted exclamation mark -bromobenzophenone

Chemical Property of 2-Amino-4'-bromobenzophenone

Chemical Property:

• Melting Point: 103-110oC
• Boiling Point: 432.5±25.0 °C(Predicted)
• PKA: -0.36±0.10(Predicted)
• Flash Point: 215.4oC
• PSA: 43.09000
• Density: 1.484±0.06 g/cm3 (20 ºC 760 Torr)
• LogP: 3.84350
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• XLogP3: 4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 274.99458
• Heavy Atom Count: 16
• Complexity: 248

Purity/Quality:

99%min ^*data from raw suppliers

(2-Aminophenyl)(4-bromophenyl)methanone ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi,N
• Hazard Codes: Xi,N
• Statements: 43-51/53
• Safety Statements: 36/37-61

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C(=C1)C(=O)C2=CC=C(C=C2)Br)N

Technology Process of 2-Amino-4'-bromobenzophenone

There total 31 articles about 2-Amino-4'-bromobenzophenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

(2-nitrophenyl)(4-bromophenyl)methanone (861781-61-5) → 2-amino-4'-bromobenzophenone (1140-17-6)

Guidance literature:

With hydrogenchloride; iron; In ethanol; water; for 1h; Reflux;

DOI:10.1021/ol100954x

Reference yield: 86.8%

4-Bromophenylboronic acid (5467-74-3) + anthranilic acid nitrile (1885-29-6) → 2-amino-4'-bromobenzophenone (1140-17-6)

Guidance literature:

With 1,2-bis(diphenylphosphino)ethane nickel(II) chloride; trifluoroacetic acid; In 1,4-dioxane; water; at 20 - 120 ℃; for 12h; Reagent/catalyst; Solvent;

Reference yield: 81.0%

2-((4-bromophenyl)sulfonamido)benzoic acid (51012-29-4) → 2-amino-4'-bromobenzophenone (1140-17-6)

Guidance literature:

With dipotassium hydrogenphosphate; [4,4′-bis(1,1-dimethylethyl)-2,2′-bipyridine-N1,N1′]bis{3,5-difluoro-2-[5-(trifluoromethyl)-2-pyridinyl-κN]phenyl-κC}iridium(III) hexafluorophosphate; triphenylphosphine; In 1,4-dioxane; at 25 ℃; for 8h; Schlenk technique; Inert atmosphere; Sealed tube; Irradiation;

DOI:10.1002/chem.201903816

upstream raw materials:

2-(4-bromo-benzoyl)-benzoic acid amide

4-bromo-benzophenone-(E)-oxime

bromobenzene

2-(Toluene-4-sulfonylamino)-benzoyl chloride

Downstream raw materials:

N-[2-(4-bromo-benzoyl)-phenyl]-phthalimide

2-azido-4'-bromo-benzophenone

2-N-(4-methylsulfonylbenzoyl)-amide-4'-bromo-benzophenone

2-N-(4-aminosulfonylbenzoyl)-amide-4'-bromo-benzophenone