Technology Process of methyl 4-[4-chloro-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]cyclohex-3-ene-1-carboxylate
There total 6 articles about methyl 4-[4-chloro-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]cyclohex-3-ene-1-carboxylate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: acetic acid / dichloromethane / 1.08 h / 10 °C
1.2: 18 h / 10 - 20 °C
2.1: hydrogen / 3percent Pt/0.6percentVG/C, deGussa / ethanol / 2.5 h / 10 °C / 2068.65 Torr / Inert atmosphere
3.1: methanesulfonic acid; isopentyl nitrite / ethanol / 0.25 h
4.1: sulfuryl dichloride / acetic acid / 17 h / 0 - 20 °C
5.1: boron tribromide / dichloromethane / 4 h / 0 - 20 °C
5.2: 0.5 h / pH > 10
5.3: pH 6 - 7
6.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.5 h / 0 °C
7.1: potassium phosphate / tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane; water / 1.5 h / 90 °C
With
potassium phosphate; sulfuryl dichloride; methanesulfonic acid; hydrogen; boron tribromide; acetic acid; N-ethyl-N,N-diisopropylamine; isopentyl nitrite;
tetrakis(triphenylphosphine) palladium(0);
In
1,4-dioxane; ethanol; dichloromethane; water; acetic acid;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: methanesulfonic acid; isopentyl nitrite / ethanol / 0.25 h
2.1: sulfuryl dichloride / acetic acid / 17 h / 0 - 20 °C
3.1: boron tribromide / dichloromethane / 4 h / 0 - 20 °C
3.2: 0.5 h / pH > 10
3.3: pH 6 - 7
4.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.5 h / 0 °C
5.1: potassium phosphate / tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane; water / 1.5 h / 90 °C
With
potassium phosphate; sulfuryl dichloride; methanesulfonic acid; boron tribromide; N-ethyl-N,N-diisopropylamine; isopentyl nitrite;
tetrakis(triphenylphosphine) palladium(0);
In
1,4-dioxane; ethanol; dichloromethane; water; acetic acid;
- Guidance literature:
-
Multi-step reaction with 2 steps
1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.5 h / 0 °C
2: potassium phosphate / tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane; water / 1.5 h / 90 °C
With
potassium phosphate; N-ethyl-N,N-diisopropylamine;
tetrakis(triphenylphosphine) palladium(0);
In
1,4-dioxane; dichloromethane; water;
