N-acetyl-4-methoxy-N-((S)-2-methoxymethylpyrrolidin-1-yl)-benzamide

Base Information

• Chemical Name: N-acetyl-4-methoxy-N-((S)-2-methoxymethylpyrrolidin-1-yl)-benzamide
• CAS No.: 1393378-75-0
• Molecular Formula: C₁₆H₂₂N₂O₄
• Molecular Weight: 306.362
• Mol file: 1393378-75-0.mol

Synonyms:N-acetyl-4-methoxy-N-((S)-2-methoxymethylpyrrolidin-1-yl)-benzamide

Chemical Property of N-acetyl-4-methoxy-N-((S)-2-methoxymethylpyrrolidin-1-yl)-benzamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of N-acetyl-4-methoxy-N-((S)-2-methoxymethylpyrrolidin-1-yl)-benzamide

There total 1 articles about N-acetyl-4-methoxy-N-((S)-2-methoxymethylpyrrolidin-1-yl)-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

4-methoxy-N-((S)-2-methoxymethylpyrrolidin-1-yl)benzamide (1393378-73-8) + acetyl chloride (75-36-5) → N-acetyl-4-methoxy-N-((S)-2-methoxymethylpyrrolidin-1-yl)-benzamide (1393378-75-0)

Guidance literature:

4-methoxy-N-((S)-2-methoxymethylpyrrolidin-1-yl)benzamide; With sodium hydride; In tetrahydrofuran; at 20 ℃; for 3h; Inert atmosphere;

acetyl chloride; In tetrahydrofuran; for 3h; Inert atmosphere; Reflux;

DOI:10.1016/j.tet.2012.06.037

Reference yield:

N-acetyl-4-methoxy-N-((S)-2-methoxymethylpyrrolidin-1-yl)-benzamide (1393378-75-0) + chlorophosphoric acid diphenyl ester (2524-64-3) → C28H31N2O7P

Guidance literature:

With potassium hexamethylsilazane; In tetrahydrofuran; toluene; at -78 ℃; for 0.5h; Inert atmosphere;

DOI:10.1016/j.tet.2012.06.037

upstream raw materials:

4-methoxy-N-((S)-2-methoxymethylpyrrolidin-1-yl)benzamide

acetyl chloride