α-(4-fluorophenyl)-α-<1-(phenylsulfonyl)-4-piperidinyl>-2-pyridinemethanol

Base Information

Chemical Name:α-(4-fluorophenyl)-α-<1-(phenylsulfonyl)-4-piperidinyl>-2-pyridinemethanol
CAS No.:131911-85-8
Molecular Formula:C₂₃H₂₃FN₂O₃S
Molecular Weight:426.512
Hs Code.:

Synonyms:α-(4-fluorophenyl)-α-<1-(phenylsulfonyl)-4-piperidinyl>-2-pyridinemethanol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of α-(4-fluorophenyl)-α-<1-(phenylsulfonyl)-4-piperidinyl>-2-pyridinemethanol

Chemical Property:

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Technology Process of α-(4-fluorophenyl)-α-<1-(phenylsulfonyl)-4-piperidinyl>-2-pyridinemethanol

There total 3 articles about α-(4-fluorophenyl)-α-<1-(phenylsulfonyl)-4-piperidinyl>-2-pyridinemethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.1%

: 109-04-6
2-bromo-pyridine

: 131912-02-2
(4-fluorophenyl)<1-(phenylsulfonyl)-4-piperidinyl>methanone

: 131911-85-8
α-(4-fluorophenyl)-α-<1-(phenylsulfonyl)-4-piperidinyl>-2-pyridinemethanol

Guidance literature:: With n-butyllithium; In tetrahydrofuran; hexane; chloroform; ethyl acetate;

Reference yield:

: 25519-78-2
4-(4-fluorobenzoyl)piperidine hydrochloride

: 131911-85-8
α-(4-fluorophenyl)-α-<1-(phenylsulfonyl)-4-piperidinyl>-2-pyridinemethanol

Guidance literature:: Multi-step reaction with 2 steps

1: 51 percent / pyridine / Ambient temperature

2: 1.) n-BuLi / 1.) THF, hexane, -65 deg C, 1 h, 2.) THF, hexane, RT, 72 h

With pyridine; n-butyllithium;
DOI:10.1021/jm00114a009

Reference yield:

: 98-09-9
benzenesulfonyl chloride

: 131911-85-8
α-(4-fluorophenyl)-α-<1-(phenylsulfonyl)-4-piperidinyl>-2-pyridinemethanol

Guidance literature:: Multi-step reaction with 2 steps

1: 51 percent / pyridine / Ambient temperature

2: 1.) n-BuLi / 1.) THF, hexane, -65 deg C, 1 h, 2.) THF, hexane, RT, 72 h

With pyridine; n-butyllithium;
DOI:10.1021/jm00114a009