N-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)acetamide

Base Information

Chemical Name:N-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)acetamide
CAS No.:16067-88-2
Molecular Formula:C10H8 N2 O3
Molecular Weight:204.185
Hs Code.:
Mol file:16067-88-2.mol

Synonyms:Acetamide,N-phthalimido- (8CI); N-Acetylaminophthalimide; NSC 238884

Suppliers and Price of N-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)acetamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 5 raw suppliers

Chemical Property of N-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)acetamide

Chemical Property:

Density:1.43g/cm³

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of N-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)acetamide

There total 2 articles about N-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 85-44-9
phthalic anhydride

: 1068-57-1
acetic acid hydrazide

: 16067-88-2
N-(1,3-dioxo-1,3-dihydroisoindol-2-yl)-acetamide

Guidance literature:: In toluene; for 3h; Heating;
DOI:10.1002/ejoc.200300445

Reference yield:

: 85-44-9
phthalic anhydride

: 16067-88-2
N-(1,3-dioxo-1,3-dihydroisoindol-2-yl)-acetamide

Guidance literature:: Multi-step reaction with 3 steps

1: tetrahydrofuran / 0.08 h / 20 °C

2: 1,3-dicyclohexylcarbodiimide / tetrahydrofuran / 1 h

3: acetic acid; triethylamine / tetrahydrofuran / 1 h / Heating

With acetic acid; triethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; 1: Acylation / 2: Cyclization / 3: Isomerization;
DOI:10.1021/jo000225s

Reference yield: 100.0%

: 16067-88-2
N-(1,3-dioxo-1,3-dihydroisoindol-2-yl)-acetamide

: 71-43-2,26181-88-4,54682-86-9,13967-78-7,174973-66-1
benzene

: 66614-79-7
N-(1,3-dioxoisoindolin-2-yl)-N-phenylacetamide

Guidance literature:: With peracetic acid; trifluoroacetic acid; 2,2’-diiodo-4,4’,6,6’-tetramethylbiphenyl; In acetic acid; 1,2-dichloro-ethane; at 20 ℃; for 12h; regioselective reaction;
DOI:10.1055/s-0037-1611661