9-cyclohexylmethyl-1-(2-nitrobenzenesulfonyl)-3-methylene-5-(p-toluenesulfonyl)-1,5,9-triazacyclododecane

Base Information

Chemical Name:9-cyclohexylmethyl-1-(2-nitrobenzenesulfonyl)-3-methylene-5-(p-toluenesulfonyl)-1,5,9-triazacyclododecane
CAS No.:1322645-42-0
Molecular Formula:C₃₀H₄₂N₄O₆S₂
Molecular Weight:618.819
Hs Code.:

Synonyms:9-cyclohexylmethyl-1-(2-nitrobenzenesulfonyl)-3-methylene-5-(p-toluenesulfonyl)-1,5,9-triazacyclododecane

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Chemical Property of 9-cyclohexylmethyl-1-(2-nitrobenzenesulfonyl)-3-methylene-5-(p-toluenesulfonyl)-1,5,9-triazacyclododecane

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Technology Process of 9-cyclohexylmethyl-1-(2-nitrobenzenesulfonyl)-3-methylene-5-(p-toluenesulfonyl)-1,5,9-triazacyclododecane

There total 8 articles about 9-cyclohexylmethyl-1-(2-nitrobenzenesulfonyl)-3-methylene-5-(p-toluenesulfonyl)-1,5,9-triazacyclododecane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

: 620161-75-3
2-methylene-1,3-propane-[bis-(tert-butyl)carbonate]

: 1322645-22-6
N-(2-nitrobenzenesulfonyl)-N'-(p-toluenesulfonyl)bis(3-aminopropyl)cyclohexylmethylamine

: 1322645-42-0
9-cyclohexylmethyl-1-(2-nitrobenzenesulfonyl)-3-methylene-5-(p-toluenesulfonyl)-1,5,9-triazacyclododecane

Guidance literature:: With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 1,4-di(diphenylphosphino)-butane; In acetonitrile; for 24h; Inert atmosphere; Reflux;
DOI:10.1021/jm2002603

Reference yield:

: C₁₇H₂₆N₂O₂S

: 1322645-42-0
9-cyclohexylmethyl-1-(2-nitrobenzenesulfonyl)-3-methylene-5-(p-toluenesulfonyl)-1,5,9-triazacyclododecane

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium tetrahydroborate / ethanol / 12 h / 20 °C / Inert atmosphere

2.1: sodium carbonate / acetonitrile / 48 h / Inert atmosphere; Reflux

3.1: hydrazine hydrate / ethanol / 3 h / Inert atmosphere; Reflux

3.2: 1.5 h / Inert atmosphere

4.1: sodium carbonate / dichloromethane; water / 24 h / 20 °C / Inert atmosphere

5.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 1,4-di(diphenylphosphino)-butane / acetonitrile / 24 h / Inert atmosphere; Reflux

With sodium tetrahydroborate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sodium carbonate; hydrazine hydrate; 1,4-di(diphenylphosphino)-butane; In ethanol; dichloromethane; water; acetonitrile;
DOI:10.1021/jm2002603

Reference yield:

: 1322644-99-4
N-(p-toluenesulfonamidopropyl)cyclohexylmethylamine

: 1322645-42-0
9-cyclohexylmethyl-1-(2-nitrobenzenesulfonyl)-3-methylene-5-(p-toluenesulfonyl)-1,5,9-triazacyclododecane

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium carbonate / acetonitrile / 48 h / Inert atmosphere; Reflux

2.1: hydrazine hydrate / ethanol / 3 h / Inert atmosphere; Reflux

2.2: 1.5 h / Inert atmosphere

3.1: sodium carbonate / dichloromethane; water / 24 h / 20 °C / Inert atmosphere

4.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 1,4-di(diphenylphosphino)-butane / acetonitrile / 24 h / Inert atmosphere; Reflux

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sodium carbonate; hydrazine hydrate; 1,4-di(diphenylphosphino)-butane; In ethanol; dichloromethane; water; acetonitrile;
DOI:10.1021/jm2002603