9-cyclohexylmethyl-1-(2-nitrobenzenesulfonyl)-3-methylene-5-(p-toluenesulfonyl)-1,5,9-triazacyclododecane hydrochloride

Base Information

Chemical Name:9-cyclohexylmethyl-1-(2-nitrobenzenesulfonyl)-3-methylene-5-(p-toluenesulfonyl)-1,5,9-triazacyclododecane hydrochloride
CAS No.:1322646-21-8
Molecular Formula:C₃₀H₄₂N₄O₆S₂*ClH
Molecular Weight:655.28
Hs Code.:

Synonyms:9-cyclohexylmethyl-1-(2-nitrobenzenesulfonyl)-3-methylene-5-(p-toluenesulfonyl)-1,5,9-triazacyclododecane hydrochloride

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Chemical Property of 9-cyclohexylmethyl-1-(2-nitrobenzenesulfonyl)-3-methylene-5-(p-toluenesulfonyl)-1,5,9-triazacyclododecane hydrochloride

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Technology Process of 9-cyclohexylmethyl-1-(2-nitrobenzenesulfonyl)-3-methylene-5-(p-toluenesulfonyl)-1,5,9-triazacyclododecane hydrochloride

There total 9 articles about 9-cyclohexylmethyl-1-(2-nitrobenzenesulfonyl)-3-methylene-5-(p-toluenesulfonyl)-1,5,9-triazacyclododecane hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: 1322645-42-0
9-cyclohexylmethyl-1-(2-nitrobenzenesulfonyl)-3-methylene-5-(p-toluenesulfonyl)-1,5,9-triazacyclododecane

: 1322646-21-8
9-cyclohexylmethyl-1-(2-nitrobenzenesulfonyl)-3-methylene-5-(p-toluenesulfonyl)-1,5,9-triazacyclododecane hydrochloride

Guidance literature:: With hydrogenchloride; In methanol; water; at 20 ℃; for 4h; Inert atmosphere;
DOI:10.1021/jm2002603

Reference yield:

: C₁₇H₂₆N₂O₂S

: 1322646-21-8
9-cyclohexylmethyl-1-(2-nitrobenzenesulfonyl)-3-methylene-5-(p-toluenesulfonyl)-1,5,9-triazacyclododecane hydrochloride

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium tetrahydroborate / ethanol / 12 h / 20 °C / Inert atmosphere

2.1: sodium carbonate / acetonitrile / 48 h / Inert atmosphere; Reflux

3.1: hydrazine hydrate / ethanol / 3 h / Inert atmosphere; Reflux

3.2: 1.5 h / Inert atmosphere

4.1: sodium carbonate / dichloromethane; water / 24 h / 20 °C / Inert atmosphere

5.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 1,4-di(diphenylphosphino)-butane / acetonitrile / 24 h / Inert atmosphere; Reflux

6.1: hydrogenchloride / methanol; water / 4 h / 20 °C / Inert atmosphere

With hydrogenchloride; sodium tetrahydroborate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sodium carbonate; hydrazine hydrate; 1,4-di(diphenylphosphino)-butane; In methanol; ethanol; dichloromethane; water; acetonitrile;
DOI:10.1021/jm2002603

Reference yield:

: 1322644-99-4
N-(p-toluenesulfonamidopropyl)cyclohexylmethylamine

: 1322646-21-8
9-cyclohexylmethyl-1-(2-nitrobenzenesulfonyl)-3-methylene-5-(p-toluenesulfonyl)-1,5,9-triazacyclododecane hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium carbonate / acetonitrile / 48 h / Inert atmosphere; Reflux

2.1: hydrazine hydrate / ethanol / 3 h / Inert atmosphere; Reflux

2.2: 1.5 h / Inert atmosphere

3.1: sodium carbonate / dichloromethane; water / 24 h / 20 °C / Inert atmosphere

4.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 1,4-di(diphenylphosphino)-butane / acetonitrile / 24 h / Inert atmosphere; Reflux

5.1: hydrogenchloride / methanol; water / 4 h / 20 °C / Inert atmosphere

With hydrogenchloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sodium carbonate; hydrazine hydrate; 1,4-di(diphenylphosphino)-butane; In methanol; ethanol; dichloromethane; water; acetonitrile;
DOI:10.1021/jm2002603