1-[4-chloro-3-(5-methylpyridin-2-yl)-phenyl]piperidine-4-carboxylic acid ethyl ester

Base Information

Chemical Name:1-[4-chloro-3-(5-methylpyridin-2-yl)-phenyl]piperidine-4-carboxylic acid ethyl ester
CAS No.:1380796-86-0
Molecular Formula:C₂₀H₂₃ClN₂O₂
Molecular Weight:358.868
Hs Code.:

Synonyms:1-[4-chloro-3-(5-methylpyridin-2-yl)-phenyl]piperidine-4-carboxylic acid ethyl ester

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Chemical Property of 1-[4-chloro-3-(5-methylpyridin-2-yl)-phenyl]piperidine-4-carboxylic acid ethyl ester

Chemical Property:

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Technology Process of 1-[4-chloro-3-(5-methylpyridin-2-yl)-phenyl]piperidine-4-carboxylic acid ethyl ester

There total 8 articles about 1-[4-chloro-3-(5-methylpyridin-2-yl)-phenyl]piperidine-4-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1126-09-6
4-carbethoxypiperidine

: 1380796-81-5
2-(5-bromo-2-chlorophenyl)-5-methylpyridine

: 1380796-86-0
1-[4-chloro-3-(5-methylpyridin-2-yl)-phenyl]piperidine-4-carboxylic acid ethyl ester

Guidance literature:: With caesium carbonate; palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In toluene; at 110 ℃; for 2h; Inert atmosphere;

Reference yield:

: 105884-19-3
1-(2-bromo-5-chlorophenyl)ethan-1-one

: 1380796-86-0
1-[4-chloro-3-(5-methylpyridin-2-yl)-phenyl]piperidine-4-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: iodine / Isopropyl acetate / 5 - 10 °C

1.2: Reflux

2.1: ammonium acetate; acetic acid / ethanol / -4 °C / Reflux

3.1: caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / palladium diacetate / toluene / 45 - 110 °C / Inert atmosphere

With ammonium acetate; iodine; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; acetic acid; palladium diacetate; In ethanol; Isopropyl acetate; toluene;

Reference yield:

: 1190947-45-5
2-(2-chloro-5-nitro-phenyl)-5-methyl-pyridine

: 1380796-86-0
1-[4-chloro-3-(5-methylpyridin-2-yl)-phenyl]piperidine-4-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogenchloride; tin(ll) chloride / ethanol; water / 3 h / 60 °C

1.2: 0 °C

2.1: sodium nitrite; hydrogen bromide / water / 0.5 h / 0 - 20 °C

2.2: 1 h / -5 - 20 °C

2.3: -5 °C

3.1: caesium carbonate / palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / toluene / 2 h / 110 °C / Inert atmosphere

With hydrogenchloride; hydrogen bromide; caesium carbonate; tin(ll) chloride; sodium nitrite; palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In ethanol; water; toluene;