(9H-Fluoren-9-yl)methyl N-<(1S)-2-methyl-1-<<<1,1-dimethyl-2--2-thioxoethyl>amino>carbonyl>propyl>carbamate

Base Information

Chemical Name:(9H-Fluoren-9-yl)methyl N-<(1S)-2-methyl-1-<<<1,1-dimethyl-2--2-thioxoethyl>amino>carbonyl>propyl>carbamate
CAS No.:212070-56-9
Molecular Formula:C₃₁H₃₅N₃O₃S
Molecular Weight:529.703
Hs Code.:

(9H-Fluoren-9-yl)methyl N-<(1S)-2-methyl-1-<<<1,1-dimethyl-2-<methyl(phenyl)amino>-2-thioxoethyl>amino>carbonyl>propyl>carbamate

Synonyms:(9H-Fluoren-9-yl)methyl N-<(1S)-2-methyl-1-<<<1,1-dimethyl-2--2-thioxoethyl>amino>carbonyl>propyl>carbamate

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Chemical Property of (9H-Fluoren-9-yl)methyl N-<(1S)-2-methyl-1-<<<1,1-dimethyl-2--2-thioxoethyl>amino>carbonyl>propyl>carbamate

Chemical Property:

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Technology Process of (9H-Fluoren-9-yl)methyl N-<(1S)-2-methyl-1-<<<1,1-dimethyl-2--2-thioxoethyl>amino>carbonyl>propyl>carbamate

There total 5 articles about (9H-Fluoren-9-yl)methyl N-<(1S)-2-methyl-1-<<<1,1-dimethyl-2--2-thioxoethyl>amino>carbonyl>propyl>carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 187884-05-5
(2S)-2-[(tert-butoxycarbonyl)amino]-3-methylbutanethioic S-acid

: 212070-56-9
(9H-Fluoren-9-yl)methyl N-<(1S)-2-methyl-1-<<<1,1-dimethyl-2--2-thioxoethyl>amino>carbonyl>propyl>carbamate

Guidance literature:: Multi-step reaction with 2 steps

1: CH₂Cl₂ / 2.5 h / Ambient temperature

2: 1.) 3M HCl, 2.) NaHCO₃ / 1.) THF, H₂O, rt, 16 h, 2.) THF, H₂O, dioxane, 14 h

With hydrogenchloride; sodium hydrogencarbonate; In dichloromethane;
DOI:10.1002/(SICI)1522-2675(19990609)82:6<888::AID-HLCA888>3.0.CO;2-5

Reference yield:

: C₁₆H₂₅N₃OS*ClH

: 28920-43-6
(fluorenylmethoxy)carbonyl chloride

: 212070-56-9
(9H-Fluoren-9-yl)methyl N-<(1S)-2-methyl-1-<<<1,1-dimethyl-2--2-thioxoethyl>amino>carbonyl>propyl>carbamate

Guidance literature:: With sodium carbonate; In tetrahydrofuran; 1,4-dioxane; water; at 20 ℃; for 20h; pH=9;

Reference yield:

: 13734-41-3
t-Boc-L-valine

: 212070-56-9
(9H-Fluoren-9-yl)methyl N-<(1S)-2-methyl-1-<<<1,1-dimethyl-2--2-thioxoethyl>amino>carbonyl>propyl>carbamate

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) NMM, isobutyl chloroformate, 2.) H₂S / 1.) THF, -10 deg C, 10 min, 2.) -10 deg C, 2 h

2: 90 percent / CH₂Cl₂ / 2 h / Ambient temperature

3: 1.) HCl / 1.) THF, H₂O, room temperature, 15 h, 2.) dioxane, water, 1 h

With 4-methyl-morpholine; hydrogenchloride; hydrogen sulfide; isobutyl chloroformate; In dichloromethane;
DOI:10.1016/S0040-4020(98)00506-7