5'-O-(4,4'-dimethoxytrityl)-3-{2-[(2,4-dinitrophenyl)amino]ethyl}thymidine

Base Information

• Chemical Name: 5'-O-(4,4'-dimethoxytrityl)-3-{2-[(2,4-dinitrophenyl)amino]ethyl}thymidine
• CAS No.: 1263363-84-3
• Molecular Formula: C₃₉H₃₉N₅O₁₁
• Molecular Weight: 753.766

Synonyms:5'-O-(4,4'-dimethoxytrityl)-3-{2-[(2,4-dinitrophenyl)amino]ethyl}thymidine

Chemical Property of 5'-O-(4,4'-dimethoxytrityl)-3-{2-[(2,4-dinitrophenyl)amino]ethyl}thymidine

Chemical Property:

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Technology Process of 5'-O-(4,4'-dimethoxytrityl)-3-{2-[(2,4-dinitrophenyl)amino]ethyl}thymidine

There total 1 articles about 5'-O-(4,4'-dimethoxytrityl)-3-{2-[(2,4-dinitrophenyl)amino]ethyl}thymidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

3-{2-[(2,4-dinitrophenyl)amino]ethyl}thymidine (1263363-83-2) + 4,4'-dimethoxytrityl chloride (40615-36-9) → 5'-O-(4,4'-dimethoxytrityl)-3-{2-[(2,4-dinitrophenyl)amino]ethyl}thymidine (1263363-84-3)

Guidance literature:

With pyridine; at 4 ℃; for 72h;

DOI:10.1002/hlca.201000253

Reference yield: 95.0%

succinic acid anhydride (108-30-5) + 5'-O-(4,4'-dimethoxytrityl)-3-{2-[(2,4-dinitrophenyl)amino]ethyl}thymidine (1263363-84-3) → 5'-O-(4,4'-dimethoxytrityl)-3-{2-[(2,4-dinitrophenyl)amino]ethyl}thymidine 3'-(hydrogen butanoate) (1263363-86-5)

Guidance literature:

With dmap; In dichloromethane; at 20 ℃; for 72h;

DOI:10.1002/hlca.201000253

Reference yield: 76.0%

5'-O-(4,4'-dimethoxytrityl)-3-{2-[(2,4-dinitrophenyl)amino]ethyl}thymidine (1263363-84-3) + N,N,N',N'-tetraisopropyl 2-cyanoethylphosphorodiamidite (102691-36-1) → 5'-O-(4,4'-dimethoxytrityl)-3-{2-[(2,4-dinitrophenyl)amino]ethyl}thymidine 3'-(2-cyanoethyl-N,N-diisopropylphosphoramidite) (1263363-85-4)

Guidance literature:

With 1H-tetrazole; In dichloromethane; acetonitrile; for 12h; Inert atmosphere;

DOI:10.1002/hlca.201000253

upstream raw materials:

3-{2-[(2,4-dinitrophenyl)amino]ethyl}thymidine

4,4'-dimethoxytrityl chloride

Downstream raw materials:

5'-O-(4,4'-dimethoxytrityl)-3-{2-[(2,4-dinitrophenyl)amino]ethyl}thymidine 3'-(hydrogen butanoate)

5'-O-(4,4'-dimethoxytrityl)-3-{2-[(2,4-dinitrophenyl)amino]ethyl}thymidine 3'-(2-cyanoethyl-N,N-diisopropylphosphoramidite)

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