(E)-2-(2-cyclohexylstyryl)pyridine

Base Information

• Chemical Name: (E)-2-(2-cyclohexylstyryl)pyridine
• CAS No.: 1624610-64-5
• Molecular Formula: C₁₃H₁₇N
• Molecular Weight: 187.285
• Mol file: 1624610-64-5.mol

Synonyms:(E)-2-(2-cyclohexylstyryl)pyridine

Chemical Property of (E)-2-(2-cyclohexylstyryl)pyridine

Chemical Property:

Purity/Quality:

Safty Information:

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• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-2-(2-cyclohexylstyryl)pyridine

There total 9 articles about (E)-2-(2-cyclohexylstyryl)pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

3-pyridin-2-yl-acrylic acid (7340-22-9) + 1,3-dioxoisoindolin-2-yl cyclohexanecarboxylate (126812-30-4) → (E)-2-(2-cyclohexylstyryl)pyridine (1624610-64-5)

Guidance literature:

With triphenylphosphine; sodium iodide; In N,N-dimethyl acetamide; at 25 ℃; for 10h; stereoselective reaction; Schlenk technique; Inert atmosphere; Irradiation;

DOI:10.1039/d0ob01242d

Reference yield: 85.0%

2-vinylpyridine (100-69-6,25014-15-7,27476-03-5,329041-71-6) + 1,3-dioxoisoindolin-2-yl cyclohexanecarboxylate (126812-30-4) → (E)-2-(2-cyclohexylstyryl)pyridine (1624610-64-5)

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; water; potassium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In N,N-dimethyl acetamide; at 25 ℃; for 24h; stereoselective reaction; Schlenk technique; Inert atmosphere; Irradiation;

DOI:10.1021/acs.orglett.8b00023

Reference yield: 77.0%

triphenyl-(2-pyridylmethyl)phosphonium chloride (38700-15-1) + cyclohexanecarbaldehyde (2043-61-0) → (E)-2-(2-cyclohexylstyryl)pyridine (1624610-64-5)

Guidance literature:

triphenyl-(2-pyridylmethyl)phosphonium chloride; With sodium hydride; In tetrahydrofuran; mineral oil; at 0 ℃; for 1h; Inert atmosphere;

cyclohexanecarbaldehyde; In tetrahydrofuran; mineral oil; at 0 - 20 ℃; for 13h; Inert atmosphere;

DOI:10.1039/c5cc10401g

upstream raw materials:

α-picoline

cyclohexanecarbaldehyde

2-vinylpyridine

Cyclohexyl iodide

Refernces

• 1、 Li, Jin-Heng,Li, Yang,Lv, Gui-Fen,Wang, Hong-Yu,Zhong, Long-Jin. "Photocatalytic dual decarboxylative alkenylation mediated by triphenylphosphine and sodium iodide". supporting information. p. 5589 - 5593. Retrieved 2020/08/21.
• 2、 Wang, Guang-Zu,Shang, Rui,Fu, Yao. "Irradiation-Induced Palladium-Catalyzed Decarboxylative Heck Reaction of Aliphatic N-(Acyloxy)phthalimides at Room Temperature". supporting information. p. 888 - 891. Retrieved 2018/02/10.