7340-22-9

Basic information

• Product Name: 3-(2-PYRIDYL)ACRYLIC ACID
• Synonyms: 3-(PYRID-2-YL)ACRYLIC ACID;3-PYRIDIN-2-YL-ACRYLIC ACID;RARECHEM AH CK 0188;3-(Pyridin-2-yl)acrylic acid 97%;2-Pyridineacrylic acid;3-(2-PYRIDYL)ACRYLIC ACID 98%;(E)-3-(Pyridin-2-yl)acrylic acid;(2E)-3-(pyridin-2-yl)prop-2-enoic acid
• CAS NO: 7340-22-9
• Molecular Formula: C₈H₇NO₂
• Molecular Weight: 149.15
• EINECS: 214-424-0
• Product Categories: Miscellaneous;pharmacetical
• Mol File: 7340-22-9.mol
• Article Data: 4

Chemical Properties

• Melting Point: 201-203°C
• Boiling Point: 304.8 °C at 760 mmHg
• Flash Point: 138.1 °C
• Appearance: /
• Density: 1.261 g/cm³
• Vapor Pressure: 0.000376mmHg at 25°C
• Refractive Index: 1.624
• Storage Temp.: Inert atmosphere,Room Temperature
• PKA: 2.06±0.10(Predicted)
• CAS DataBase Reference: 3-(2-PYRIDYL)ACRYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(2-PYRIDYL)ACRYLIC ACID(7340-22-9)
• EPA Substance Registry System: 3-(2-PYRIDYL)ACRYLIC ACID(7340-22-9)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 7340-22-9(Hazardous Substances Data)

Usage

General Description

3-(2-pyridyl)acrylic acid is a chemical compound with the molecular formula C7H7NO2. It is also known as 3-pyridylacrylic acid or 2-(3-pyridinyl)-2-propenoic acid. 3-(2-PYRIDYL)ACRYLIC ACID is a white to pale yellow solid that is soluble in water and organic solvents. It is often used as a building block in organic synthesis and as a starting material for the preparation of various pharmaceuticals and agrochemicals. 3-(2-pyridyl)acrylic acid has been studied for its potential applications in the development of new drugs, particularly in the area of cancer research. It is important to handle this compound with care, as it can be harmful if it comes into contact with the skin or eyes.

InChI:InChI=1/C8H7NO2/c10-8(11)5-4-7-3-1-2-6-9-7/h1-6H,(H,10,11)/b5-4-

Upstream product

• 1121-60-4 pyridine-2-carbaldehyde 
• 141-82-2 malonic acid 

Downstream Products

• 1624610-64-5 (E)-2-(2-cyclohexylstyryl)pyridine 
• 99310-43-7 3-[2]piperidyl-propionic acid ; hydrochloride 
• 1186240-28-7 N-((1-(3-(1-(4-chloro-2,5-dimethylphenylsulfonyl)piperidin-2-yl)propanoyl)-4-(4-methylpiperazin-1-yl)piperidin-4-yl)methyl)acetamide 
• 1021204-82-9 3-[1-(4-chloro-2,5-dimethyl-phenylsulfonyl)-piperidin-2-yl]-propionic acid 
• 1021204-95-4 methyl 3-[1-(4-chloro-2,5-dimethyl-phenylsulfonyl)-piperidin-2-yl]-propionate 
• 56759-30-9 (E)-4-methylphenyl 2-(2-pyridinyl)ethenyl sulfone 
• 153583-38-1 (E)-1-(pyridine-2-yl)-2-phenylsulfonylethene 
• 50610-14-5 methyl 3-(pyridin-2-yl)acrylate 
• 64107-57-9 2-[2-(3-Bromo-pyridin-2-ylmethylsulfanyl)-ethylamino]-5-pyridin-2-ylmethyl-1H-pyrimidin-4-one; hydrobromide 
• 64107-50-2 2-[2-(5-Methyl-1H-imidazol-4-ylmethylsulfanyl)-ethylamino]-5-pyridin-2-ylmethyl-1H-pyrimidin-4-one; hydrochloride 
• 2739-74-4 ethyl 3-(2-pyridinyl)propanoate 
• 15197-75-8 3-(pyridin-2-yl)propanoic acid 
• 7340-23-0 (E)-ethyl 3-(2-pyridyl)-propenoate 

Relevant articles and documents

Preparation method of 2-pyridylacrylic acid

The invention belongs to the field of organic synthesis, and in particular, relates to a preparation method of 2-pyridylacrylic acid. The method comprises the following steps: by taking 2-pyridylaldehyde as a raw material and pyridine as a solvent, adding malonic acid, adding a catalyst after complete dissolution, heating to 60-70 DEG C, carrying out a reaction for 2.5-3 h, performing thin-layer chromatography tracking reaction, after the reaction is completed, cooling the reaction liquid to 0-5 DEG C, then pouring into an ice-water mixture of concentrated hydrochloric acid, separating out solids, and carrying out suction filtration to obtain the required product 2-pyridylacrylic acid. The method has the beneficial effects that the reaction conditions are mild, the operation is easy, the post-treatment is simple, the scale-up production is easy, and the method is quite suitable for industrial production; the catalytic effect is good, and the yield is high; the raw materials are cheap and the production cost is low.

Preparation method of 2-pyridine acrylic acid

The invention belongs to the field of organic synthesis, and particularly relates to a preparation method of 2-pyridine acrylic acid. The method includes following steps: taking 2-pyridylaldehyde as araw material and pyridine as a solvent, adding malonic acid, adding a catalyst after complete dissolution, rising temperature to 60-70 DEG C, allowing reaction for 2.5-3h, allowing thin-layer chromatography tracking reaction, cooling reaction liquid to 0-5 DEG C after reaction is completed, pouring the reaction liquid into an ice-water mixture of concentrated hydrochloric acid, separating out solid, and performing suction filtering to obtain 2-pyridine acrylic acid. The method has the advantages of being mild in reaction condition, easy in operation, simple in aftertreatment, easy in amplifying production, quite suitable for industrial production, good in catalytic effect, high in yield, low in raw material cost and low in production cost.