(E)-4-(5-(1-acetylpiperidin-4-yl)-2-(3-(3-chloro-2-fluoro-6-(1H-tetrazol-1-yl)phenyl)acryloyl)-1,2,3,4-tetrahydroisoquinoline-1-carboxamido)benzoic acid

Base Information

Chemical Name:(E)-4-(5-(1-acetylpiperidin-4-yl)-2-(3-(3-chloro-2-fluoro-6-(1H-tetrazol-1-yl)phenyl)acryloyl)-1,2,3,4-tetrahydroisoquinoline-1-carboxamido)benzoic acid
CAS No.:1430562-76-7
Molecular Formula:C₃₄H₃₁ClFN₇O₅
Molecular Weight:672.115
Hs Code.:

(E)-4-(5-(1-acetylpiperidin-4-yl)-2-(3-(3-chloro-2-fluoro-6-(1H-tetrazol-1-yl)phenyl)acryloyl)-1,2,3,4-tetrahydroisoquinoline-1-carboxamido)benzoic acid

Synonyms:(E)-4-(5-(1-acetylpiperidin-4-yl)-2-(3-(3-chloro-2-fluoro-6-(1H-tetrazol-1-yl)phenyl)acryloyl)-1,2,3,4-tetrahydroisoquinoline-1-carboxamido)benzoic acid

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Chemical Property of (E)-4-(5-(1-acetylpiperidin-4-yl)-2-(3-(3-chloro-2-fluoro-6-(1H-tetrazol-1-yl)phenyl)acryloyl)-1,2,3,4-tetrahydroisoquinoline-1-carboxamido)benzoic acid

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Technology Process of (E)-4-(5-(1-acetylpiperidin-4-yl)-2-(3-(3-chloro-2-fluoro-6-(1H-tetrazol-1-yl)phenyl)acryloyl)-1,2,3,4-tetrahydroisoquinoline-1-carboxamido)benzoic acid

There total 13 articles about (E)-4-(5-(1-acetylpiperidin-4-yl)-2-(3-(3-chloro-2-fluoro-6-(1H-tetrazol-1-yl)phenyl)acryloyl)-1,2,3,4-tetrahydroisoquinoline-1-carboxamido)benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1094107-98-8
(E)-3-(3-chloro-2-fluoro-6-(tetrazol-1-yl)phenyl)acrylic acid 2,5-dioxopyrrolidin-1-yl ester

: C₂₅H₂₇N₃O₆

: 1430562-76-7
(E)-4-(5-(1-acetylpiperidin-4-yl)-2-(3-(3-chloro-2-fluoro-6-(1H-tetrazol-1-yl)phenyl)acryloyl)-1,2,3,4-tetrahydroisoquinoline-1-carboxamido)benzoic acid

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; for 24h;

Reference yield:

: 1109230-24-1
methyl 2-(2-bromophenyl)ethylcarbamate

: 1430562-76-7
(E)-4-(5-(1-acetylpiperidin-4-yl)-2-(3-(3-chloro-2-fluoro-6-(1H-tetrazol-1-yl)phenyl)acryloyl)-1,2,3,4-tetrahydroisoquinoline-1-carboxamido)benzoic acid

Guidance literature:: Multi-step reaction with 11 steps

1.1: acetic acid; sulfuric acid / 0 - 20 °C

2.1: sodium hydroxide / ethanol; 1,4-dioxane / 0.5 h / 150 °C / Microwave irradiation

3.1: sodium hydroxide / 1,4-dioxane / 2 h

4.1: thionyl chloride / 50 °C

5.1: lithium chloride; bis-triphenylphosphine-palladium(II) chloride / toluene / 24 h / 100 °C / Inert atmosphere

6.1: hydrogen; platinum(IV) oxide / ethanol / 24 h / 2844.39 Torr

6.2: 24 h

7.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 24 h

8.1: lithium hydroxide; water / tetrahydrofuran / 3 h

9.1: trichlorophosphate; pyridine / dichloromethane / 3 h / 0 °C

10.1: trifluoroacetic acid / dichloromethane / 1 h

11.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 24 h

With pyridine; platinum(IV) oxide; bis-triphenylphosphine-palladium(II) chloride; thionyl chloride; sulfuric acid; water; hydrogen; acetic acid; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; lithium chloride; sodium hydroxide; lithium hydroxide; trichlorophosphate; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1430563-92-0
5-bromo-2-(tert-butoxycarbonyl)-3,4-dihydroisoquinoline-1-carboxylic acid methyl ester

: 1430562-76-7
(E)-4-(5-(1-acetylpiperidin-4-yl)-2-(3-(3-chloro-2-fluoro-6-(1H-tetrazol-1-yl)phenyl)acryloyl)-1,2,3,4-tetrahydroisoquinoline-1-carboxamido)benzoic acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: lithium chloride; bis-triphenylphosphine-palladium(II) chloride / toluene / 24 h / 100 °C / Inert atmosphere

2.1: hydrogen; platinum(IV) oxide / ethanol / 24 h / 2844.39 Torr

2.2: 24 h

3.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 24 h

4.1: lithium hydroxide; water / tetrahydrofuran / 3 h

5.1: trichlorophosphate; pyridine / dichloromethane / 3 h / 0 °C

6.1: trifluoroacetic acid / dichloromethane / 1 h

7.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 24 h

With pyridine; platinum(IV) oxide; bis-triphenylphosphine-palladium(II) chloride; water; hydrogen; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; lithium chloride; lithium hydroxide; trichlorophosphate; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide; toluene;