1H-3-Benzazepine-7,8-diol, 6-bromo-2,3,4,5-tetrahydro-1-(4-hydroxyphenyl)-3-(2-propenyl)-

Base Information

Chemical Name:1H-3-Benzazepine-7,8-diol, 6-bromo-2,3,4,5-tetrahydro-1-(4-hydroxyphenyl)-3-(2-propenyl)-
CAS No.:104421-90-1
Molecular Formula:C₁₉H₂₀BrNO₃
Molecular Weight:390.277
Hs Code.:
Mol file:104421-90-1.mol

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1H-3-Benzazepine-7,8-diol, 6-bromo-2,3,4,5-tetrahydro-1-(4-hydroxyphenyl)-3-(2-propenyl)-

Chemical Property:

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Technology Process of 1H-3-Benzazepine-7,8-diol, 6-bromo-2,3,4,5-tetrahydro-1-(4-hydroxyphenyl)-3-(2-propenyl)-

There total 9 articles about 1H-3-Benzazepine-7,8-diol, 6-bromo-2,3,4,5-tetrahydro-1-(4-hydroxyphenyl)-3-(2-propenyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 104421-89-8
3-Allyl-6-bromo-7,8-dimethoxy-1-(4-methoxy-phenyl)-2,3,4,5-tetrahydro-1H-benzo[d]azepine

: 104421-90-1
3-allyl-6-bromo-2,3,4,5-tetrahydro-1-(4-hydroxyphenyl)-1H-3-benzazepine-7,8-diol

Guidance literature:: With boron tribromide; In dichloromethane; for 2h; Ambient temperature;
DOI:10.1021/jm00384a006

Reference yield:

: 33646-40-1
4-methoxymandelonitrile

: 104421-90-1
3-allyl-6-bromo-2,3,4,5-tetrahydro-1-(4-hydroxyphenyl)-1H-3-benzazepine-7,8-diol

Guidance literature:: Multi-step reaction with 6 steps

1: 37 percent / BH₃ / tetrahydrofuran

2: 31.6 g / aq. K₂CO₃ / toluene / Ambient temperature

3: BH₃ / tetrahydrofuran / 3 h / Heating

4: conc. H₂SO₄ / trifluoroacetic acid / 0.33 h / Heating

5: 76 percent / K₂CO₃ / dimethylformamide; H₂O; CH₂Cl₂ / Ambient temperature

6: BBr₃ / CH₂Cl₂ / 2 h / Ambient temperature

With sulfuric acid; borane; boron tribromide; potassium carbonate; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; toluene; trifluoroacetic acid;
DOI:10.1021/jm00384a006

Reference yield:

: 72912-39-1
(2-bromo-3,4-dimethoxyphenyl)acetonitrile

: 104421-90-1
3-allyl-6-bromo-2,3,4,5-tetrahydro-1-(4-hydroxyphenyl)-1H-3-benzazepine-7,8-diol

Guidance literature:: Multi-step reaction with 7 steps

1: 84 percent / H₂SO₄ / aq. acetic acid / 2 h / Heating

2: SOCl₂ / CH₂Cl₂ / Heating

3: 31.6 g / aq. K₂CO₃ / toluene / Ambient temperature

4: BH₃ / tetrahydrofuran / 3 h / Heating

5: conc. H₂SO₄ / trifluoroacetic acid / 0.33 h / Heating

6: 76 percent / K₂CO₃ / dimethylformamide; H₂O; CH₂Cl₂ / Ambient temperature

7: BBr₃ / CH₂Cl₂ / 2 h / Ambient temperature

With thionyl chloride; sulfuric acid; borane; boron tribromide; potassium carbonate; In tetrahydrofuran; dichloromethane; water; acetic acid; N,N-dimethyl-formamide; toluene; trifluoroacetic acid;
DOI:10.1021/jm00384a006