4-(2,6-dichlorophenyl)-8-methylsulfanyl-1,2-dihydro-3a,7,9,9b-tetraazacyclopenta[a]naphthalen-3-one

Base Information

• Chemical Name: 4-(2,6-dichlorophenyl)-8-methylsulfanyl-1,2-dihydro-3a,7,9,9b-tetraazacyclopenta[a]naphthalen-3-one
• CAS No.: 909095-79-0
• Molecular Formula: C₁₆H₁₂Cl₂N₄OS
• Molecular Weight: 379.269
• Mol file: 909095-79-0.mol

Synonyms:4-(2,6-dichlorophenyl)-8-methylsulfanyl-1,2-dihydro-3a,7,9,9b-tetraazacyclopenta[a]naphthalen-3-one

Chemical Property of 4-(2,6-dichlorophenyl)-8-methylsulfanyl-1,2-dihydro-3a,7,9,9b-tetraazacyclopenta[a]naphthalen-3-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(2,6-dichlorophenyl)-8-methylsulfanyl-1,2-dihydro-3a,7,9,9b-tetraazacyclopenta[a]naphthalen-3-one

There total 7 articles about 4-(2,6-dichlorophenyl)-8-methylsulfanyl-1,2-dihydro-3a,7,9,9b-tetraazacyclopenta[a]naphthalen-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

1-{5-[2-(2,6-dichlorophenyl)-3-oxoethyl]-2-methylsulfanylpyrimidin-4-yl}pyrazolidin-3-one (909095-78-9) → 4-(2,6-dichlorophenyl)-8-methylsulfanyl-1,2-dihydro-3a,7,9,9b-tetraazacyclopenta[a]naphthalen-3-one (909095-79-0)

Guidance literature:

With toluene-4-sulfonic acid; In toluene; Heating;

DOI:10.1016/j.bmcl.2006.05.072

Reference yield:

4-chloro-5-methyl-2-(methylsulfanyl)pyrimidine (61044-96-0) → 4-(2,6-dichlorophenyl)-8-methylsulfanyl-1,2-dihydro-3a,7,9,9b-tetraazacyclopenta[a]naphthalen-3-one (909095-79-0)

Guidance literature:

Multi-step reaction with 4 steps

1: 66 percent / N-bromosuccinimide / benzoyl peroxide / 1,2-dichloro-ethane / 2 h / Heating

2: 39 percent / LDA / tetrahydrofuran; heptane; ethylbenzene / 2 h / -78 °C

3: 32 percent / N,N-diisopropylethylamine / dimethylformamide / 3 h / 80 °C

4: 1.8 g / p-TsOH monohydrate; molecular sieves / toluene / 4 h / Heating

With N-Bromosuccinimide; molecular sieve; toluene-4-sulfonic acid; N-ethyl-N,N-diisopropylamine; lithium diisopropyl amide; dibenzoyl peroxide; In tetrahydrofuran; n-heptane; ethylbenzene; 1,2-dichloro-ethane; N,N-dimethyl-formamide; toluene;

DOI:10.3987/com-06-10806

Reference yield:

4-(2,6-dichlorophenyl)-4-hydroxy-8-methylsulfanyl-1,2,4,5-tetrahydro-3a,7,9,9b-tetraazacyclopenta[a]naphthalen-3-one (916907-11-4) → 4-(2,6-dichlorophenyl)-8-methylsulfanyl-1,2-dihydro-3a,7,9,9b-tetraazacyclopenta[a]naphthalen-3-one (909095-79-0)

Guidance literature:

With molecular sieve; toluene-4-sulfonic acid; In toluene; at 130 ℃;

DOI:10.3987/com-06-10806

upstream raw materials:

1-{5-[2-(2,6-dichlorophenyl)-3-oxoethyl]-2-methylsulfanylpyrimidin-4-yl}pyrazolidin-3-one

4-(2,6-dichlorophenyl)-4-hydroxy-8-methylsulfanyl-1,2,4,5-tetrahydro-3a,7,9,9b-tetraazacyclopenta[a]naphthalen-3-one

5-bromomethyl-4-chloro-2-(methylthio)pyrimidine

2-(4-chloro-2-methylsulfanylpyrimidin-5-yl)-1-(2,6-dichlorophenyl)ethanone

Downstream raw materials:

4-(2,6-dichlorophenyl)-8-methylsulfinyl-1,2-dihydro-3a,7,9,9b-tetraazacyclopenta[a]naphthalen-3-one