Technology Process of methyl 4-(3-(acetoxymethyl)-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)butanoate
There total 14 articles about methyl 4-(3-(acetoxymethyl)-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)butanoate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate;
In
1,4-dioxane;
at 85 ℃;
for 16h;
Inert atmosphere;
DOI:10.1016/j.bmcl.2010.12.034
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.25 h / -78 °C
1.2: 2 h / 20 °C
2.1: sodium dihydrogenphosphate; sodium chlorite; 2-methyl-but-2-ene / tert-butyl alcohol / 1.5 h / 20 °C
3.1: potassium carbonate / N,N-dimethyl-formamide / 0.33 h / 20 °C
3.2: 1 h / 20 °C
4.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate / 1,4-dioxane / 16 h / 85 °C / Inert atmosphere
With
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; oxalyl dichloride; potassium acetate; potassium carbonate; dimethyl sulfoxide;
In
1,4-dioxane; dichloromethane; N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1016/j.bmcl.2010.12.034
- Guidance literature:
-
Multi-step reaction with 9 steps
1.1: N,N-dimethyl-formamide / 1 h / 80 °C
2.1: formic acid; water / 1 h / 100 °C
3.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C
3.2: 20 h / -78 - 20 °C
4.1: 10% palladium on activated carbon; hydrogen / ethyl acetate / 1 h / 20 °C
5.1: hydrogenchloride; water / methanol; ethyl acetate / 0.5 h / 40 °C
6.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.25 h / -78 °C
6.2: 2 h / 20 °C
7.1: sodium dihydrogenphosphate; sodium chlorite; 2-methyl-but-2-ene / tert-butyl alcohol / 1.5 h / 20 °C
8.1: potassium carbonate / N,N-dimethyl-formamide / 0.33 h / 20 °C
8.2: 1 h / 20 °C
9.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate / 1,4-dioxane / 16 h / 85 °C / Inert atmosphere
With
hydrogenchloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium chlorite; sodium dihydrogenphosphate; n-butyllithium; formic acid; 2-methyl-but-2-ene; oxalyl dichloride; 10% palladium on activated carbon; water; hydrogen; potassium acetate; potassium carbonate; dimethyl sulfoxide;
In
tetrahydrofuran; 1,4-dioxane; methanol; hexane; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; tert-butyl alcohol;
3.2: Wittig reaction;
DOI:10.1016/j.bmcl.2010.12.034
