Technology Process of methyl 4-(3-(acetoxymethyl)-2-bromophenyl)butanoate
There total 13 articles about methyl 4-(3-(acetoxymethyl)-2-bromophenyl)butanoate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
4-(3-(acetoxymethyl)-2-bromophenyl)butanoic acid;
With
potassium carbonate;
In
N,N-dimethyl-formamide;
at 20 ℃;
for 0.333333h;
methyl iodide;
In
N,N-dimethyl-formamide;
at 20 ℃;
for 1h;
DOI:10.1016/j.bmcl.2010.12.034
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C
1.2: 20 h / -78 - 20 °C
2.1: 10% palladium on activated carbon; hydrogen / ethyl acetate / 1 h / 20 °C
3.1: hydrogenchloride; water / methanol; ethyl acetate / 0.5 h / 40 °C
4.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.25 h / -78 °C
4.2: 2 h / 20 °C
5.1: sodium dihydrogenphosphate; sodium chlorite; 2-methyl-but-2-ene / tert-butyl alcohol / 1.5 h / 20 °C
6.1: potassium carbonate / N,N-dimethyl-formamide / 0.33 h / 20 °C
6.2: 1 h / 20 °C
With
hydrogenchloride; sodium chlorite; sodium dihydrogenphosphate; n-butyllithium; 2-methyl-but-2-ene; oxalyl dichloride; 10% palladium on activated carbon; water; hydrogen; potassium carbonate; dimethyl sulfoxide;
In
tetrahydrofuran; methanol; hexane; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; tert-butyl alcohol;
1.2: Wittig reaction;
DOI:10.1016/j.bmcl.2010.12.034
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: formic acid; water / 1 h / 100 °C
2.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C
2.2: 20 h / -78 - 20 °C
3.1: 10% palladium on activated carbon; hydrogen / ethyl acetate / 1 h / 20 °C
4.1: hydrogenchloride; water / methanol; ethyl acetate / 0.5 h / 40 °C
5.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.25 h / -78 °C
5.2: 2 h / 20 °C
6.1: sodium dihydrogenphosphate; sodium chlorite; 2-methyl-but-2-ene / tert-butyl alcohol / 1.5 h / 20 °C
7.1: potassium carbonate / N,N-dimethyl-formamide / 0.33 h / 20 °C
7.2: 1 h / 20 °C
With
hydrogenchloride; sodium chlorite; sodium dihydrogenphosphate; n-butyllithium; formic acid; 2-methyl-but-2-ene; oxalyl dichloride; 10% palladium on activated carbon; water; hydrogen; potassium carbonate; dimethyl sulfoxide;
In
tetrahydrofuran; methanol; hexane; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; tert-butyl alcohol;
2.2: Wittig reaction;
DOI:10.1016/j.bmcl.2010.12.034
