(7S,8S)-7-(2-methoxy-4-(2-methyloctan-2-yl)phenyl)-1,4-dioxaspiro[4.5]decan-8-ol

Base Information

Chemical Name:(7S,8S)-7-(2-methoxy-4-(2-methyloctan-2-yl)phenyl)-1,4-dioxaspiro[4.5]decan-8-ol
CAS No.:1374219-10-9
Molecular Formula:C₂₄H₃₈O₄
Molecular Weight:390.563
Hs Code.:

Synonyms:(7S,8S)-7-(2-methoxy-4-(2-methyloctan-2-yl)phenyl)-1,4-dioxaspiro[4.5]decan-8-ol

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Chemical Property of (7S,8S)-7-(2-methoxy-4-(2-methyloctan-2-yl)phenyl)-1,4-dioxaspiro[4.5]decan-8-ol

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Technology Process of (7S,8S)-7-(2-methoxy-4-(2-methyloctan-2-yl)phenyl)-1,4-dioxaspiro[4.5]decan-8-ol

There total 9 articles about (7S,8S)-7-(2-methoxy-4-(2-methyloctan-2-yl)phenyl)-1,4-dioxaspiro[4.5]decan-8-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 1374219-11-0
C₂₄H₃₆O₄

: 1374219-10-9
(7S,8S)-7-(2-methoxy-4-(2-methyloctan-2-yl)phenyl)-1,4-dioxaspiro[4.5]decan-8-ol

Guidance literature:: With C₅₅H₅₀Cl₂N₂P₂Ru; potassium tert-butylate; hydrogen; In isopropyl alcohol; at 20 ℃; for 12h; under 38002.6 Torr; optical yield given as %ee; enantioselective reaction; Inert atmosphere;
DOI:10.1002/adsc.201100898

Reference yield:

: 4683-24-3
1,4-dioxa-spiro[4.5]dec-6-en-8-one

: 1374219-10-9
(7S,8S)-7-(2-methoxy-4-(2-methyloctan-2-yl)phenyl)-1,4-dioxaspiro[4.5]decan-8-ol

Guidance literature:: Multi-step reaction with 4 steps

1: dmap; iodine; potassium carbonate / tetrahydrofuran; water / 2 h / 20 °C

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; lithium chloride / 1,2-dimethoxyethane; water / 12 h / 80 °C / Inert atmosphere

3: 5%-palladium/activated carbon; hydrogen / ethanol / 3 h / 30 °C / 760.05 Torr

4: C₅₅H₅₀Cl₂N₂P₂Ru; potassium tert-butylate; hydrogen / isopropyl alcohol / 12 h / 20 °C / 38002.6 Torr / Inert atmosphere

With dmap; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 5%-palladium/activated carbon; C₅₅H₅₀Cl₂N₂P₂Ru; potassium tert-butylate; hydrogen; iodine; sodium carbonate; potassium carbonate; lithium chloride; In tetrahydrofuran; 1,2-dimethoxyethane; ethanol; water; isopropyl alcohol; 2: Suzuki coupling;
DOI:10.1002/adsc.201100898

Reference yield:

: 866398-21-2
1-(1,1-dimethylheptyl)-3-methoxybenzene

: 1374219-10-9
(7S,8S)-7-(2-methoxy-4-(2-methyloctan-2-yl)phenyl)-1,4-dioxaspiro[4.5]decan-8-ol

Guidance literature:: Multi-step reaction with 5 steps

1.1: bromine / acetic acid / 4 h / 20 °C

2.1: n-butyllithium / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

2.2: 1.5 h / -78 - -30 °C / Inert atmosphere

3.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; lithium chloride / 1,2-dimethoxyethane; water / 12 h / 80 °C / Inert atmosphere

4.1: 5%-palladium/activated carbon; hydrogen / ethanol / 3 h / 30 °C / 760.05 Torr

5.1: C₅₅H₅₀Cl₂N₂P₂Ru; potassium tert-butylate; hydrogen / isopropyl alcohol / 12 h / 20 °C / 38002.6 Torr / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; 5%-palladium/activated carbon; C₅₅H₅₀Cl₂N₂P₂Ru; potassium tert-butylate; hydrogen; bromine; sodium carbonate; lithium chloride; In tetrahydrofuran; 1,2-dimethoxyethane; ethanol; water; acetic acid; isopropyl alcohol; 3.1: Suzuki coupling;
DOI:10.1002/adsc.201100898