Technology Process of O-(7S,8S)-7-[2-methoxy-4-(2-methyloctan-2-yl)phenyl]-1,4-dioxaspiro[4.5]decan-8-yl S-methyl carbonodithioate
There total 10 articles about O-(7S,8S)-7-[2-methoxy-4-(2-methyloctan-2-yl)phenyl]-1,4-dioxaspiro[4.5]decan-8-yl S-methyl carbonodithioate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
(7S,8S)-7-(2-methoxy-4-(2-methyloctan-2-yl)phenyl)-1,4-dioxaspiro[4.5]decan-8-ol;
With
sodium hydride;
In
tetrahydrofuran;
at 0 - 20 ℃;
for 0.5h;
Inert atmosphere;
carbon disulfide;
In
tetrahydrofuran;
at 20 ℃;
for 0.75h;
methyl iodide;
In
tetrahydrofuran;
at 20 ℃;
for 0.75h;
DOI:10.1002/adsc.201100898
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: dmap; iodine; potassium carbonate / tetrahydrofuran; water / 2 h / 20 °C
2.1: tetrakis(triphenylphosphine) palladium(0); sodium carbonate; lithium chloride / 1,2-dimethoxyethane; water / 12 h / 80 °C / Inert atmosphere
3.1: 5%-palladium/activated carbon; hydrogen / ethanol / 3 h / 30 °C / 760.05 Torr
4.1: C55H50Cl2N2P2Ru; potassium tert-butylate; hydrogen / isopropyl alcohol / 12 h / 20 °C / 38002.6 Torr / Inert atmosphere
5.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 - 20 °C / Inert atmosphere
5.2: 0.75 h / 20 °C
5.3: 0.75 h / 20 °C
With
dmap; tetrakis(triphenylphosphine) palladium(0); 5%-palladium/activated carbon; C55H50Cl2N2P2Ru; potassium tert-butylate; hydrogen; iodine; sodium hydride; sodium carbonate; potassium carbonate; lithium chloride;
In
tetrahydrofuran; 1,2-dimethoxyethane; ethanol; water; isopropyl alcohol;
2.1: Suzuki coupling;
DOI:10.1002/adsc.201100898
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: bromine / acetic acid / 4 h / 20 °C
2.1: n-butyllithium / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere
2.2: 1.5 h / -78 - -30 °C / Inert atmosphere
3.1: tetrakis(triphenylphosphine) palladium(0); sodium carbonate; lithium chloride / 1,2-dimethoxyethane; water / 12 h / 80 °C / Inert atmosphere
4.1: 5%-palladium/activated carbon; hydrogen / ethanol / 3 h / 30 °C / 760.05 Torr
5.1: C55H50Cl2N2P2Ru; potassium tert-butylate; hydrogen / isopropyl alcohol / 12 h / 20 °C / 38002.6 Torr / Inert atmosphere
6.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 - 20 °C / Inert atmosphere
6.2: 0.75 h / 20 °C
6.3: 0.75 h / 20 °C
With
tetrakis(triphenylphosphine) palladium(0); n-butyllithium; 5%-palladium/activated carbon; C55H50Cl2N2P2Ru; potassium tert-butylate; hydrogen; bromine; sodium hydride; sodium carbonate; lithium chloride;
In
tetrahydrofuran; 1,2-dimethoxyethane; ethanol; water; acetic acid; isopropyl alcohol;
3.1: Suzuki coupling;
DOI:10.1002/adsc.201100898
