1-phenyl-cycloheptanecarboxylic acid (S)-(1-aza-bicyclo[2.2.2]oct-3-yl)ester

Base Information

Chemical Name:1-phenyl-cycloheptanecarboxylic acid (S)-(1-aza-bicyclo[2.2.2]oct-3-yl)ester
CAS No.:1196093-11-4
Molecular Formula:C₂₁H₂₉NO₂
Molecular Weight:327.467
Hs Code.:

Synonyms:1-phenyl-cycloheptanecarboxylic acid (S)-(1-aza-bicyclo[2.2.2]oct-3-yl)ester

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Chemical Property of 1-phenyl-cycloheptanecarboxylic acid (S)-(1-aza-bicyclo[2.2.2]oct-3-yl)ester

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Technology Process of 1-phenyl-cycloheptanecarboxylic acid (S)-(1-aza-bicyclo[2.2.2]oct-3-yl)ester

There total 9 articles about 1-phenyl-cycloheptanecarboxylic acid (S)-(1-aza-bicyclo[2.2.2]oct-3-yl)ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 94163-02-7
methyl 1-phenylcycloheptanecarboxylate

: 3684-26-2,25333-42-0,34583-34-1,1619-34-7
(S)-quinuclidin-3-ol

: 1196093-11-4
1-phenyl-cycloheptanecarboxylic acid (S)-(1-aza-bicyclo[2.2.2]oct-3-yl)ester

Guidance literature:: With sodium hydride; In toluene; mineral oil; for 24h; Inert atmosphere; Reflux;

Reference yield:

: 32730-85-1
cycloheptanecarbonitrile

: 1196093-11-4
1-phenyl-cycloheptanecarboxylic acid (S)-(1-aza-bicyclo[2.2.2]oct-3-yl)ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: diethyl ether / 3 h / Inert atmosphere; Reflux

1.2: 0 - 90 °C

2.1: sulfuryl dichloride / 1 h / 0 °C

2.2: Reflux

3.1: water / silver nitrate / 1,4-dioxane / 4.5 h / 75 °C

4.1: trimethylsilyldiazomethane / toluene / 0.75 h / Inert atmosphere

5.1: sodium hydride / toluene; mineral oil / 24 h / Inert atmosphere; Reflux

With sulfuryl dichloride; water; sodium hydride; trimethylsilyldiazomethane; silver nitrate; In 1,4-dioxane; diethyl ether; toluene; mineral oil;

Reference yield:

: 502-42-1
cycloheptanone

: 1196093-11-4
1-phenyl-cycloheptanecarboxylic acid (S)-(1-aza-bicyclo[2.2.2]oct-3-yl)ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: iodine; magnesium / tetrahydrofuran / 0.33 h / Inert atmosphere; Reflux

1.2: 0.17 h

2.1: sodium hydride / tetrahydrofuran; mineral oil / 0.08 h / 60 °C

2.2: 60 °C / Reflux

3.1: potassium; sodium / diethyl ether / 20 °C / Inert atmosphere

3.2: -78 - 20 °C / Inert atmosphere

3.3: pH 7

4.1: trimethylsilyldiazomethane / toluene / 0.75 h / Inert atmosphere

5.1: sodium hydride / toluene; mineral oil / 24 h / Inert atmosphere; Reflux

With iodine; sodium; potassium; sodium hydride; magnesium; trimethylsilyldiazomethane; In tetrahydrofuran; diethyl ether; toluene; mineral oil;