17-[4',5'-dihydro-5'-methyl-4'-(p-chlorophenylamino)-3'-phenyl-1'H-pyrazol-5'-yl]androst-4-ene-3-one

Base Information

Chemical Name:17-[4',5'-dihydro-5'-methyl-4'-(p-chlorophenylamino)-3'-phenyl-1'H-pyrazol-5'-yl]androst-4-ene-3-one
CAS No.:1321919-28-1
Molecular Formula:C₃₅H₄₂ClN₃O
Molecular Weight:556.191
Hs Code.:

Synonyms:17-[4',5'-dihydro-5'-methyl-4'-(p-chlorophenylamino)-3'-phenyl-1'H-pyrazol-5'-yl]androst-4-ene-3-one

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Chemical Property of 17-[4',5'-dihydro-5'-methyl-4'-(p-chlorophenylamino)-3'-phenyl-1'H-pyrazol-5'-yl]androst-4-ene-3-one

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Technology Process of 17-[4',5'-dihydro-5'-methyl-4'-(p-chlorophenylamino)-3'-phenyl-1'H-pyrazol-5'-yl]androst-4-ene-3-one

There total 5 articles about 17-[4',5'-dihydro-5'-methyl-4'-(p-chlorophenylamino)-3'-phenyl-1'H-pyrazol-5'-yl]androst-4-ene-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1321919-35-0
17-[2'-hydroxy-4'-oxo-4'-phenyl-3'-(p-chlorophenylamino)butan-2-yl]androst-4-en-3-one

: 1321919-28-1
17-[4',5'-dihydro-5'-methyl-4'-(p-chlorophenylamino)-3'-phenyl-1'H-pyrazol-5'-yl]androst-4-ene-3-one

Guidance literature:: With hydrazine hydrate; triethylamine; In ethanol; Reflux;
DOI:10.1016/j.steroids.2011.05.011

Reference yield:

: 1321919-25-8
17-(3'-benzoyl-2'-methyloxiran-2'-yl)androst-4-ene-3-one

: 1321919-28-1
17-[4',5'-dihydro-5'-methyl-4'-(p-chlorophenylamino)-3'-phenyl-1'H-pyrazol-5'-yl]androst-4-ene-3-one

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / ethanol / Reflux

2: hydrazine hydrate; triethylamine / ethanol / Reflux

With hydrazine hydrate; triethylamine; In ethanol;
DOI:10.1016/j.steroids.2011.05.011

Reference yield:

: 57-83-0
Progesterone

: 1321919-28-1
17-[4',5'-dihydro-5'-methyl-4'-(p-chlorophenylamino)-3'-phenyl-1'H-pyrazol-5'-yl]androst-4-ene-3-one

Guidance literature:: Multi-step reaction with 3 steps

1: potassium; tert-butyl alcohol / 30 h / 20 - 70 °C

2: triethylamine / ethanol / Reflux

3: hydrazine hydrate; triethylamine / ethanol / Reflux

With potassium; hydrazine hydrate; triethylamine; tert-butyl alcohol; In ethanol; 1: Darzens condensation;
DOI:10.1016/j.steroids.2011.05.011