17-[2'-hydroxy-4'-oxo-4'-phenyl-3'-(p-chlorophenylamino)butan-2-yl]androst-4-en-3-one

Base Information

• Chemical Name: 17-[2'-hydroxy-4'-oxo-4'-phenyl-3'-(p-chlorophenylamino)butan-2-yl]androst-4-en-3-one
• CAS No.: 1321919-35-0
• Molecular Formula: C₃₅H₄₂ClNO₃
• Molecular Weight: 560.176
• Mol file: 1321919-35-0.mol

Synonyms:17-[2'-hydroxy-4'-oxo-4'-phenyl-3'-(p-chlorophenylamino)butan-2-yl]androst-4-en-3-one

Chemical Property of 17-[2'-hydroxy-4'-oxo-4'-phenyl-3'-(p-chlorophenylamino)butan-2-yl]androst-4-en-3-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 17-[2'-hydroxy-4'-oxo-4'-phenyl-3'-(p-chlorophenylamino)butan-2-yl]androst-4-en-3-one

There total 1 articles about 17-[2'-hydroxy-4'-oxo-4'-phenyl-3'-(p-chlorophenylamino)butan-2-yl]androst-4-en-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Progesterone (57-83-0) → 17-[2'-hydroxy-4'-oxo-4'-phenyl-3'-(p-chlorophenylamino)butan-2-yl]androst-4-en-3-one (1321919-35-0)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium; tert-butyl alcohol / 30 h / 20 - 70 °C

2: triethylamine / ethanol / Reflux

With potassium; triethylamine; tert-butyl alcohol; In ethanol; 1: Darzens condensation;

DOI:10.1016/j.steroids.2011.05.011

Reference yield: 83.0%

17-[2'-hydroxy-4'-oxo-4'-phenyl-3'-(p-chlorophenylamino)butan-2-yl]androst-4-en-3-one (1321919-35-0) + phenyl isothiocyanate (103-72-0) → 20-hydroxy-20-[3',4'-diphenyl-1'-(p-chlorophenyl)-2'-thioxo-1',3'-imidazol-5'-yl]pregn-4-ene-3-one (1321919-54-3)

Guidance literature:

With triethylamine; In ethanol; Reflux;

DOI:10.1016/j.steroids.2011.05.011

Reference yield: 80.0%

17-[2'-hydroxy-4'-oxo-4'-phenyl-3'-(p-chlorophenylamino)butan-2-yl]androst-4-en-3-one (1321919-35-0) → 17-[4',5'-dihydro-5'-methyl-4'-(p-chlorophenylamino)-3'-phenyl-1'H-pyrazol-5'-yl]androst-4-ene-3-one (1321919-28-1)

Guidance literature:

With hydrazine hydrate; triethylamine; In ethanol; Reflux;

DOI:10.1016/j.steroids.2011.05.011

upstream raw materials:

Progesterone

Downstream raw materials:

17-[4',5'-dihydro-5'-methyl-4'-(p-chlorophenylamino)-3'-phenyl-1'H-pyrazol-5'-yl]androst-4-ene-3-one

20-hydroxy-20-[3',4'-diphenyl-1'-(p-chlorophenyl)-2'-thioxo-1',3'-imidazol-5'-yl]pregn-4-ene-3-one

17-[4',5'-dihydro-1,3'-diphenyl-5'-methyl-4'-(p-chlorophenylamino)pyrazol-5'-yl]androst-4-ene-3-one