N-[4-(3-chloro-4-methoxy-benzylamino)-7-methoxy-8-(2-oxo-ethyl)-quinazolin-6-yl]-acetamide

Base Information

• Chemical Name: N-[4-(3-chloro-4-methoxy-benzylamino)-7-methoxy-8-(2-oxo-ethyl)-quinazolin-6-yl]-acetamide
• CAS No.: 1007308-16-8
• Molecular Formula: C₂₁H₂₁ClN₄O₄
• Molecular Weight: 428.875
• Mol file: 1007308-16-8.mol

Synonyms:N-[4-(3-chloro-4-methoxy-benzylamino)-7-methoxy-8-(2-oxo-ethyl)-quinazolin-6-yl]-acetamide

Chemical Property of N-[4-(3-chloro-4-methoxy-benzylamino)-7-methoxy-8-(2-oxo-ethyl)-quinazolin-6-yl]-acetamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-[4-(3-chloro-4-methoxy-benzylamino)-7-methoxy-8-(2-oxo-ethyl)-quinazolin-6-yl]-acetamide

There total 11 articles about N-[4-(3-chloro-4-methoxy-benzylamino)-7-methoxy-8-(2-oxo-ethyl)-quinazolin-6-yl]-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

7-chloro-6-nitro-4(3H)-quinazolinone (53449-14-2) → N-[4-(3-chloro-4-methoxy-benzylamino)-7-methoxy-8-(2-oxo-ethyl)-quinazolin-6-yl]-acetamide (1007308-16-8)

Guidance literature:

Multi-step reaction with 11 steps

1: thionyl chloride / N,N-dimethyl-formamide / 17 h / 20 °C / Heating / reflux

2: triethylamine / N,N-dimethyl-formamide / isopropyl alcohol / 17 h / 20 °C

3: methanol / 16 h / Heating / reflux

4: lithium chloride / N,N-dimethyl-formamide / 5 h / 150 °C

5: potassium carbonate / acetone / 6 h / 80 °C

6: xylene / 2 h / 150 °C

7: potassium carbonate / acetone / 5 h / 20 °C / Heating / reflux

8: tin(ll) chloride / ethanol / 12 h / Heating / reflux

9: pyridine / dmap / ethanol / 18 h / 20 °C

10: 4-methyl-morpholine; osmium(VIII) oxide / water; acetone / 6 h / 0 - 20 °C

11: sodium periodate / methanol; water / 0.5 h / 0 °C

With 4-methyl-morpholine; pyridine; sodium periodate; osmium(VIII) oxide; thionyl chloride; potassium carbonate; triethylamine; lithium chloride; tin(ll) chloride; dmap; N,N-dimethyl-formamide; In methanol; ethanol; water; N,N-dimethyl-formamide; isopropyl alcohol; acetone; xylene;

Reference yield:

N-[4-(3-chloro-4-methoxy-benzylamino)-8-(2,3-dihydroxy-propyl)-7-methoxy-quinazolin-6-yl]-acetamide (1007308-15-7) → N-[4-(3-chloro-4-methoxy-benzylamino)-7-methoxy-8-(2-oxo-ethyl)-quinazolin-6-yl]-acetamide (1007308-16-8)

Guidance literature:

With sodium periodate; In methanol; water; at 0 ℃; for 0.5h;

Reference yield:

C19H17ClN4O4 (1007308-62-4) → N-[4-(3-chloro-4-methoxy-benzylamino)-7-methoxy-8-(2-oxo-ethyl)-quinazolin-6-yl]-acetamide (1007308-16-8)

Guidance literature:

Multi-step reaction with 6 steps

1: xylene / 2 h / 150 °C

2: potassium carbonate / acetone / 5 h / 20 °C / Heating / reflux

3: tin(ll) chloride / ethanol / 12 h / Heating / reflux

4: pyridine / dmap / ethanol / 18 h / 20 °C

5: 4-methyl-morpholine; osmium(VIII) oxide / water; acetone / 6 h / 0 - 20 °C

6: sodium periodate / methanol; water / 0.5 h / 0 °C

With 4-methyl-morpholine; pyridine; sodium periodate; osmium(VIII) oxide; potassium carbonate; tin(ll) chloride; dmap; In methanol; ethanol; water; acetone; xylene;

upstream raw materials:

N-[4-(3-chloro-4-methoxy-benzylamino)-8-(2,3-dihydroxy-propyl)-7-methoxy-quinazolin-6-yl]-acetamide

C₁₉H₁₇ClN₄O₄

C₂₀H₂₁ClN₄O₂

(8-allyl-7-methoxy-6-nitro-quinazolin-4-yl)-(3-chloro-4-methoxy-benzyl)-amine