methyl 3-((6-(2,4-difluorophenyl)pyridine-2-yl)amino)-4-methylbenzoate

Base Information

Chemical Name:methyl 3-((6-(2,4-difluorophenyl)pyridine-2-yl)amino)-4-methylbenzoate
CAS No.:1380281-58-2
Molecular Formula:C₂₀H₁₆F₂N₂O₂
Molecular Weight:354.356
Hs Code.:

Synonyms:methyl 3-((6-(2,4-difluorophenyl)pyridine-2-yl)amino)-4-methylbenzoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of methyl 3-((6-(2,4-difluorophenyl)pyridine-2-yl)amino)-4-methylbenzoate

Chemical Property:

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Technology Process of methyl 3-((6-(2,4-difluorophenyl)pyridine-2-yl)amino)-4-methylbenzoate

There total 2 articles about methyl 3-((6-(2,4-difluorophenyl)pyridine-2-yl)amino)-4-methylbenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

: 18595-18-1
3-amino-4-methyl benzoic acid methyl ester

: 1380281-57-1
2-bromo-6-(2,4-difluorophenyl)pyridine

: 1380281-58-2
methyl 3-((6-(2,4-difluorophenyl)pyridine-2-yl)amino)-4-methylbenzoate

Guidance literature:: With caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; palladium diacetate; In toluene; at 85 ℃; for 18h;

Reference yield:

: 144025-03-6
2,4-difluorophenylboronic acid

: 1380281-58-2
methyl 3-((6-(2,4-difluorophenyl)pyridine-2-yl)amino)-4-methylbenzoate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / ethanol; water / 2.5 h / 75 °C

2: caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / palladium diacetate / toluene / 18 h / 85 °C

With sodium carbonate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium diacetate; In ethanol; water; toluene; 1: Suzuki Coupling;